Kirito et al., Blood 2003
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We first analyzed the effects of TPO on Hoxb4 expression in primitive hematopoietic cell lines ; TPO increased expression of the gene 2- to 3-fold in EML and UT-7/TPO cells
Kaushansky et al., Ann N Y Acad Sci 2005
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We found that TPO enhances the transcription of HoxB4 , induces the nuclear localization of HoxA9, and upregulates VEGF expression by reducing the ubiquination of hypoxia inducible factor