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TLR4 — XBP1

Text-mined interactions from Literome

Martinon et al., Nat Immunol 2010 (Tularemia) : TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages ... Instead, TLR activated XBP1 was required for optimal and sustained production of proinflammatory cytokines in macrophages
Lee et al., J Immunol 2012 (Lupus Nephritis) : We show that acute signaling through IL-6R or CD40 integrates with chronic BCR mediated ERK activation to restrict p-ERK from the nucleus and represses TLR4 induced Blimp-1 and XBP-1 expression