Gene interactions and pathways from curated databases and text-mining

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CIITA — STAT1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Sakatsume et al., Kidney Int 2000 (Glomerulonephritis) : Overexpression of Stat1-mutant lacking 35 C-terminal amino acids strongly suppressed the IFN-gamma induced signal transduction and inhibited the expression of MHC class II and CIITA genes in mesangial cells
Barbaro et al., Eur J Immunol 2002 : Block of Stat-1 activation in macrophages phagocytosing bacteria causes reduced transcription of CIITA and consequent impaired antigen presentation
Xi et al., Mol Immunol 2003 : The IFN-gamma activation of the CIITA type IV promoter is mediated by STAT1 and IRF-1, which bind to the GAS and IRF-E of the promoter, respectively
Kwon et al., Mol Immunol 2007 : In addition, although IRF-1 is a key transcription factor to activate the IFN-gamma inducible CIITA promoter, the effect of PKCdelta on CIITA expression is mediated primarily by serine phosphorylation of Stat 1
D'Agostino et al., J Biol Chem 2012 : STAT1 is an activator of CIITA , the class II transactivator for MHC II expression ; CIITA expression was concomitantly increased in IE-Cpr-null mice
Muhlethaler-Mottet et al., Immunity 1998 : Activation of the MHC class II transactivator CIITA by interferon-gamma requires cooperative interaction between Stat1 and USF-1
Piskurich et al., J Immunol 1998 : A role for STAT1 in regulation of the CIITA promoter is shown by the rescue of IFN-gamma induction by expression of STAT1 in STAT1-defective U3A cells
Lin et al., J Immunol 1998 : Thus, thyroid hormone potentiation of IFN-gamma induced HLA-DR transcription is mediated by a cell membrane hormone binding site, enhanced activation of STAT1alpha , and increased CIITA induction