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FGF9 — RUNX2
Text-mined interactions from Literome
Kim et al., J Biol Chem 2003
:
The protein kinase C pathway plays a central role in the
fibroblast growth factor stimulated expression and transactivation activity of
Runx2 ... Fibroblast growth factor ( FGF )
/FGF receptor ( FGFR ) signaling
induces the expression of
Runx2 , a key transcription factor in osteoblast differentiation, but little is known about the molecular signaling mechanisms that mediate this ... Thus, we show for the first time that
FGF/FGFR signaling
stimulates the DNA binding and transcriptional activities of
Runx2 as well as its expression, and these are largely regulated by the PKC pathway
Aberg et al., Dev Biol 2004
:
Runx2 mediates
FGF signaling from epithelium to mesenchyme during tooth morphogenesis
Yu et al., Chin Med J (Engl) 2007
(MAP Kinase Signaling System) :
Effect of
fibroblast growth factor 9 on
Runx2 gene promoter activity in MC3T3-E1 and C2C12 cells ... Here we examined the
effect of
FGF9 on the activity of the murine
Runt related transcription factor 2 ( Runx2 ) gene promoter in preosteoblast MC3T3-E1 and premyoblast C2C12 cells ...
FGF9 ( 10 ng/ml )
increased Runx2 promoter activity in MC3T3-E1 cells ... Among the above inhibitors, only U0126 ( 10 micromol/L ) completely blocked the
effects of
FGF9 on
Runx2 gene promoter activity ... Our data showed that
FGF9 can
affect Runx2 gene promoter activity in MC3T3-E1 and C2C12 cells
Park et al., J Biol Chem 2010
:
However, the molecular mechanism underlying
Runx2 activation by
FGF/FGFR or ERK was still unclear
Lu et al., Dev Dyn 2012
:
Molecular studies on the
roles of
Runx2 and Twist1 in regulating
FGF signaling ... In this study, we assessed the
roles of
Runx2 and its functional antagonist Twist1 in regulating
fibroblast growth factor ( FGF ) signaling using in vitro biochemical approaches