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PTBP2 — TSLP
Text-mined interactions from Literome
Soumelis et al., Nat Immunol 2002
(Dermatitis, Atopic) :
We show here that human
thymic stromal lymphopoietin (TSLP) potently
activated CD11c ( + )
dendritic cells (DCs) and induced production of the T ( H ) 2-attracting chemokines TARC ( thymus and activation regulated chemokine ; also known as CCL17 ) and MDC ( macrophage derived chemokine ; CCL22 )
Gilliet et al., J Exp Med 2003
(Hypersensitivity...) :
Here, we show that
TSLP activated CD11c+
DCs potently activate and expand naive CD8+ T cells, and induce their differentiation into interleukin (IL)-5 and IL-13 producing effectors exhibiting poor cytolytic activity
Soumelis et al., Springer Semin Immunopathol 2004
(Hypersensitivity...) :
TSLP activated human
DCs produce Th2 attracting chemokines but no IL-12, and induce naive CD4 ( + ) and CD8 ( + ) T cell differentiation into effector cells with a typical pro-allergic phenotype
Watanabe et al., Blood 2005
(Dermatitis, Atopic...) :
We previously showed that human
thymic stromal lymphopoietin (TSLP) , highly expressed by keratinocytes of atopic dermatitis,
activates CD11c ( + )
DCs to induce the differentiation of naive CD4 ( + ) and CD8 ( + ) T cells into proallergic effectors
Ito et al., J Exp Med 2005
:
We conclude that OX40L on
TSLP activated
DCs triggers Th2 cell polarization in the absence of IL-12, and propose that OX40L can switch IL-10 producing regulatory Th cell responses into TNF-alpha producing inflammatory Th cell responses
Lin et al., Clin Immunol 2008
(Embryo Loss) :
Thymic stromal lymphopoietin (TSLP)-TSLP receptor (TSLP-R) interactions
activate CD11c ( + )
dendritic cells (DCs) and increase epithelial cell Th2-type cytokine production ... Murine recombinant
TSLP activated
DCs from BALB/c mice, with increased CD80 and CD83 expressions ; TSLP activated DCs induced IL-10 producing NK cell expansion
Lee et al., Immunol Cell Biol 2008
:
Human
thymic stromal lymphopoietin (TSLP) activates
dendritic cells (DCs) , which promote the proliferation and differentiation of CD4+ T cells
Kamekura et al., Cell Tissue Res 2009
(Rhinitis, Allergic, Perennial) :
The nasal-epithelial derived
TSLP thus not only
activates DCs but also preserves the epithelial barrier via the upregulation of tight-junction proteins, thereby regulating antigen sensitization during the early stage of allergic rhinitis
Li et al., J Asthma 2010
(Asthma...) :
In the lung inflammation model,
TSLP activates
dendritic cells (DCs) via up-regulation of CD40, CD80, and CD86, then induces the differentiation of prime naive CD4 ( + ) T cells to become proinflammatory Th2 cells
Sugimoto et al., Clin Immunol 2010
:
While BCG stimulated DCs induced CD8 ( + ) T cell production of IFN-gamma without strong cell expansion,
TSLP stimulated
DCs induced robust CD8 ( + ) T cell expansion without high quantities of IFN-gamma production
De Monte et al., J Exp Med 2011
(Pancreatic Neoplasms) :
TSLP containing supernatants from activated CAFs
induced in vitro myeloid
DCs to up-regulate the
TSLP receptor (TSLPR) , secrete Th2 attracting chemokines, and acquire TSLP dependent Th2 polarizing capability in vitro
Zhao et al., Cell Physiol Biochem 2012
(Atherosclerosis...) :
Thymic stromal lymphopoietin (TSLP) can
activate DCs and trigger adaptive immune responses
Chen et al., PloS one 2013
(Airway Remodeling...) :
Thymic stromal lymphopoietin (TSLP) , an epithelium derived cytokine, can strongly
activate lung
dendritic cells (DCs) through the TSLP-TSLPR and OX40L-OX40 signaling pathways to promote Th2 differentiation