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MAP3K1 — POLDIP2

Text-mined interactions from Literome

Yu et al., J Biol Chem 2000 : Here we report that chelerythrine induced time- and dose dependent activation of JNK1 and p38 in HeLa cells, which was mediated the upstream kinases, MEKK1 and MKK4
Gallagher et al., Nat Immunol 2007 : Kinase MEKK1 is required for CD40 dependent activation of the kinases Jnk and p38 , germinal center formation, B cell proliferation and antibody production
Sun et al., Oncol Rep 2011 : MEKK1/MEKK4 are responsible for TRAIL induced JNK/p38 phosphorylation ... We found that MEKK1/MEKK4 as opposed to ASK1, are responsible for TRAIL induced c-Jun NH2-terminal kinase (JNK) or p38 activation, and that their catalytic activity is repressed by the caspase-8 inhibitor, suggesting that the caspase-8 activation induced by TRAIL is indispensible for MEKK activation