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HPCA — PLD2

Text-mined interactions from Literome

Hyun et al., Mol Cells 2000 : Role of hippocalcin in Ca2+ -induced activation of phospholipase D ... While hippocalcin alone did not activate PLD , it increased PLD activity activated with Cdc42 1.8-fold in the presence of calcium ( 300 nM free calcium )
Oh et al., J Cell Biochem 2006 : Hippocalcin increases phospholipase D2 expression through extracellular signal regulated kinase activation and lysophosphatidic acid potentiates the hippocalcin induced phospholipase D2 expression ... Here, we proposed that hippocalcin was involved in extracellular signal regulated kinase ( ERK ) -mediated PLD2 expression ... However, downregulation of PKC and treatment of a chelator of extracellular Ca2+, EGTA had little or no effect on the inhibition of hippocalcin induced PLD2 expression potentiated by LPA in the hippocalcin transfected cells ... Specific inhibition of ERK dramatically abolished hippocalcin induced PLD2 expression ... Taken together, these results suggest for the first time that hippocalcin can induce PLD2 expression and LPA potentiates hippocalcin induced PLD2 expression, which is mediated by ERK activation