◀ Back to PLD1
PLD1 — PRKAR2A
Text-mined interactions from Literome
Mamoon et al., J Pharmacol Exp Ther 1999
:
Protein kinase A (PKA) inhibitors H-89 and KT5720 significantly decreased forskolin- and isoproterenol
mediated activation of
PLD activity ... These results suggest that increasing the concentration of cAMP activates PLD via activation of PKA and that the increased activity of
PKA also
inhibits cholinergic stimulation of
PLD , in part at least by inhibiting the activation of phospholipase C by ACh
Thibault et al., J Leukoc Biol 2002
:
The activator of
protein kinase A (PKA) , Sp-cAMP
inhibited fMLP induced
PLD activation and translocation of Arf and RhoA to membranes
Choi et al., Ann N Y Acad Sci 2002
:
Here we review the evidence that ( 1 ) the synergistic interactions of cholera toxin and other pharmacological agents on mast cell secretion are attributable to the synergistic
activation of
PLD via
PKA , CaM kinase II, and PKC and ( 2 ) both PLD1 and PLD2 participate in this process
Cohen et al., Dev Biol 2004
:
Protein kinase A (PKA) , known to be active in sperm capacitation, and protein kinase C ( PKC ), involved in the acrosome reaction, can both
activate PLD and actin polymerization ... We suggest that
PKA- and PKC dependent signal transduction pathways can potentially
lead to
PLD activation ; however, under physiological conditions, actin polymerization depends primarily on PKA activity
Jang et al., Exp Mol Med 2004
:
These results suggest that both PLD1 and RhoA are phosphorylated by
PKA and the interaction between
PLD1 and RhoA is
inhibited by the phosphorylation of RhoA rather than by the phosphorylation of PLD1
Yoon et al., FEBS Lett 2005
:
To investigate the
involvement of
protein kinase A (PKA) , Src, and Ras in 8-Br-cAMP induced
PLD activation, we used PKA inhibitor, H89 and Rp-cAMPs, and transfections of DN-Src and DN-Ras ... H-89 and Rp-cAMPs completely blocked 8-Br-cAMP mediated PLD and ERK activation, implying the
involvement of
PKA in this
PLD activation
Breitbart et al., Mol Cell Endocrinol 2006
:
Protein kinase A (PKA) and C ( PKC ) can both
activate sperm
PLD and actin polymerization under in vitro incubation, however under physiological conditions, actin polymerization depends primarily on PKA activity
Vorland et al., Platelets 2008
:
Further studies using inhibitors as well as specific activators of protein kinases A and G suggest a
role for
PKA in the inhibition of thrombin activated
PLD ... We found that PGE ( 1 ), forskolin and the
PKA activator
inhibited PLD1 translocation in thrombin stimulated platelets, and that the PKG-activator had no effect ... The present results suggest a
role for
PKA in the regulation of thrombin induced
PLD1 activity and translocation in platelets
Cho et al., Biochem J 2011
:
Interestingly, dual inhibition of
PKA and Ras completely
inhibited PLD1 expression and cAMP induced decidualization ... These results suggest that
PLD1 expression during decidualization is
controlled additively by
PKA and Ras
Kessels et al., Biochem J 1993
:
Taken together, our results indicate that in human neutrophils : ( i ) PKC activity is not essential for fMLP induced activation of PLD; (ii) PKC activity does play an essential role in the activation of the respiratory burst by fMLP, other than mediating or modulating PLD activation ; ( iii ) there exists a negative-feedback mechanism on fMLP induced
PLD activation by concomitant activation of
PKA