Gene interactions and pathways from curated databases and text-mining

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PCNA — PI3

Text-mined interactions from Literome

Medina et al., J Biol Chem 2000 : Moreover, TSH through PKA pathway increases cyclin dependent kinase 2 levels, whereas PI 3-kinase signaling increases cyclin E levels
Uttamsingh et al., J Biol Chem 2003 : In conclusion, we have adopted an experimental system enabling us to study the signaling pathways in cells grown under anchorage independent conditions and have identified matrix independent activation of PI 3-kinase and Stat3 signaling functions, as well as the PI 3-kinase dependent increase of cyclin A-associated Cdk2 kinase activity, to be critical for the Ros-PTK induced anchorage independent growth