◀ Back to PI3

GAB1 — PI3

Text-mined interactions from Literome

Janez et al., J Biol Chem 2000 : Furthermore, phosphorylated Gab-1 binds and activates phosphatidylinositol 3-kinase (PI3K) in response to osmotic shock
Ong et al., Proc Natl Acad Sci U S A 2001 : Assembly of FRS2alpha : Grb2 : Gab1 complex induced by FGF stimulation results in activation of PI3-kinase and downstream effector proteins such as the S/T kinase Akt, whose cellular localization and activity are regulated by products of PI3-kinase
Bisotto et al., Biochem J 2001 : Taken together, our data indicate that PI 3-kinase and Src-family tyrosine kinases regulate ET-1 induced Gab1 tyrosine phosphorylation, which, in turn, induces ERK1 activation via PI 3-kinase- and SHP-2 dependent pathways
Bourguignon et al., J Biol Chem 2003 (Breast Neoplasms...) : Phosphorylated Gab-1 promotes PI 3-kinase recruitment to CD44v3
Lamothe et al., Mol Cell Biol 2004 : We demonstrate that Gab1 is essential for FGF1 stimulation of both PI 3-kinase and the antiapoptotic protein kinase Akt, while FGF1 induced mitogen activated protein kinase ( MAPK ) stimulation is not affected by Gab1 deficiency
Basar et al., Infect Immun 2005 : However, in contrast to the situation in cells expressing wild-type Met, Gab1 phosphorylation in MetYF cells required PI 3-kinase activity