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EGFR — NOTCH1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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Gene Ontology Complexes receptor complex:
receptor complex complex (PTH1R-TAOK2-VLDLR-TGFBR2-GABRG1-KCTD8-EGFR-RET-NTRK1-RIPK1-INSR-TRPC1-INSRR-GABRA5-FLT4-ADCYAP1R1-GPR37-P2RX2-LOXL4-IMPG2-PKD1L3-NOTCH1-ADRA2A-TRADD-LRP2-MTTP-GPR101-ITLN1-VIPR1-CD200R1-GRM7-GPR84-FCRL5-RNMT-ITGB1-NPR1-SLITRK5-IL4R-KCTD12-PLA2R1-RAMP1-RXRA-RAMP2-PIGR-GPR62-GPR63-GPR61-ITPR3-GPR20-MTNR1A-ROR1-ABCG5-CR2-GPR37L1-LRP1-LRP6-KCTD16-LRP5-CR1L-NTRK2-APP-GABRQ-CSF1-ABCG8-ADRB2-ADRB3-TLR7-GPR119-TAS1R2)
Roka et al., Mol Pharmacol 1999, Small et al., J Biol Chem 2000, Graf et al., J Biol Chem 2003, Breit et al., J Biol Chem 2004, Bomberger et al., J Biol Chem 2005, Turunen et al., Nucleic Acids Res 2007, Ding et al., J Cell Biol 2008, Ghai et al., Proc Natl Acad Sci U S A 2013, Lin et al., J Biol Chem 1995, Hsu et al., Immunity 1996, Zhang et al., Nature 1996
Text-mined interactions from Literome
Li et al., J Biol Chem 2007
(Skin Neoplasms) :
Interestingly, the up-regulation of
EGFR is
independent of
Notch signaling, suggesting that the EGFR pathway functions in parallel with Notch in the tumorigenesis of SCC
Purow et al., Carcinogenesis 2008
(Brain Neoplasms...) :
Notch-1 regulates transcription of the
epidermal growth factor receptor through p53 ... Experiments with p53 positive and -null cell lines confirmed that p53 partially mediates the
effects of
Notch-1 on
EGFR expression ... These results show for the first time that
Notch-1 upregulates
EGFR expression and also demonstrate Notch-1 regulation of p53 in gliomas
Osipo et al., Oncogene 2008
(Breast Neoplasms) :
Trastuzumab or a dual
epidermal growth factor receptor (EGFR)/ErbB-2 tyrosine kinase inhibitor ( TKI )
increased Notch activity by 2- to 6-fold in SKBr3, BT474 and MCF-7/HER2-18 cells
Huang et al., Br J Oral Maxillofac Surg 2010
(Carcinoma, Squamous Cell...) :
The blocking of
EGFR signalling or the silencing of the EGFR gene
resulted in upregulation of
Notch1 at mRNA and protein levels in Tca8113 cells
Aguirre et al., Nature 2010
:
This occurs through a non-cell-autonomous mechanism involving
EGFR mediated regulation of
Notch signalling
Fassl et al., Oncogene 2012
(Glioblastoma) :
Notch1 dependent regulation of Mcl-1 occurs cell type dependent at a transcriptional or post-translational level and is
mediated by the induction of
epidermal growth factor receptor (EGFR)
Kitade et al., Genes Dev 2013
:
Conversely,
EGFR selectively
induced NOTCH1 to promote cholangiocyte specification and branching morphogenesis while concomitantly suppressing hepatocyte commitment