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MAFA — NEUROD1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Raum et al., Mol Cell Biol 2010
:
Further support for the importance of R3 was also shown, as the islet regulators Nkx6.1 and Pax6, but not
NeuroD1 ,
activated MafA in gel shift, chromatin immunoprecipitation ( ChIP ), and transfection assays and in vivo mouse knockout models
Aguayo-Mazzucato et al., Diabetologia 2011
:
Similar overexpression of
MAFA resulted in increased
Neurod1 , Nkx6-1, Gck and Glp1r mRNAs and no change in insulin content but, importantly, acquisition of glucose-responsive insulin secretion