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IL12RB2 — IL4

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL12-mediated signaling events: IL4 (IL4) → IL12Rbeta2/JAK2 complex (IL12RB2-JAK2) (modification, inhibits)
  Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
  Evidence: mutant phenotype, assay, physical interaction, other species

Text-mined interactions from Literome

Galbiati et al., Eur J Immunol 2000 : IL-4 is not required for down-regulation of IL-12Rbeta2 transcripts and inhibition of Th1 development in mice pretreated with soluble protein, as shown by their reduction in IL-4-deficient BALB/c mice
Zhang et al., J Interferon Cytokine Res 2000 : Corrective effects of interleukin-12 on age related deficiencies in IFN-gamma production and IL-12Rbeta2 expression in virus-specific CD8+ T cells
Padigel et al., J Immunol 2001 (Leishmaniasis, Cutaneous) : At wk 9 of infection, we detected similar levels of IL-4 , IFN-gamma, IL-12p40, and IL-12Rbeta2 mRNA in draining lymph nodes of healing C57BL/6, CD28 ( -/- ), and CD40L ( -/- ) CD28 ( -/- ) mice, whereas CD40L ( -/- ) mice had increased mRNA levels for IL-4 but reduced levels for IFN-gamma, IL-12p40, and IL-12Rbeta2
Smeltz et al., J Immunol 2002 : However, in the presence of IL-4, IFN-gamma functions to limit the negative effects of IL-4 on both IL-18Ralpha and IL-12Rbeta2
Harris et al., J Immunol 2005 : We show that culturing naive B cells with Th2 cells induces up-regulation of IL-4 in the B cells with a concomitant down-regulation of T-bet, IL-12Rbeta2 , and IFN-gamma
Naume et al., Cytokine 1993 : The increased IL-4R expression induced by IL-12 and the increased IL-12R expression induced by IL-4 may explain the synergistic proliferative activity detected in response to IL-12 and IL-4
Szabo et al., J Exp Med 1997 : IL-4 inhibited IL-12R beta 2 expression leading to the loss of IL-12 signaling, providing an important point of regulation to promote commitment to the Th2 pathway ... IFN-gamma treatment of early developing Th2 cells maintained IL-12R beta 2 expression and restored the ability of these cells to functionally respond to IL-12, but did not directly inhibit IL-4 or induce IFN-gamma production
Himmelrich et al., J Immunol 1998 (Leishmaniasis, Cutaneous) : The down-regulation of the IL-12R beta2-chain mRNA expression in BALB/c CD4+ T cells is a consequence of the early IL-4 production