◀ Back to IL10
IL10 — IL21
Text-mined interactions from Literome
Qiu et al., Zhongguo Yao Li Xue Bao 1999
:
Inhibitory
effects of nitric oxide and
interleukin-10 on production of tumor necrosis factor alpha,
interleukin-1 beta, and interleukin-6 in mouse alveolar macrophages
Kelly et al., Reproduction 2001
:
Prostaglandins have major effects on cytokine production but the direct action of prostaglandin E on leucocytes is not a pro-inflammatory response but is to stimulate
interleukin 10 and
inhibit interleukin 12 synthesis
Byrnes et al., Ann Neurol 2002
(Multiple Sclerosis, Chronic Progressive...) :
Interleukin-10 , a dominant endogenous
inhibitor of
interleukin-12 , is largely protective in these experimental surrogates for multiple sclerosis
Puliti et al., Arthritis Rheum 2002
(Arthritis, Infectious...) :
The beneficial effect of
interleukin-12 on arthritis induced by group B streptococci is
mediated by interferon-gamma and
interleukin-10 production
Uchimura et al., Clin Exp Immunol 2002
(Graves Disease) :
The
effects of CD40- and
interleukin ( IL-4 ) -activated CD23+ cells on the production of
IL-10 by mononuclear cells in Graves ' disease : the role of CD8+ cells
Cattaruzza et al., J Biol Chem 2003
:
Interleukin-10 induction of nitric-oxide synthase expression
attenuates CD40 mediated
interleukin-12 synthesis in human endothelial cells
Chiang et al., Am J Respir Crit Care Med 2003
(Asthma...) :
The data showed that ribavirin and ODN 1826 increased
interleukin-12 synthesis and
inhibited interleukin-10 production
Jani et al., Plant Cell Rep 2004
:
Macrophages isolated from mice immunised with native or plant expressed CTB showed enhanced secretion of
interleukin-10 but secretion of lipopolysaccharide induced
interleukin-12 and tumor necrosis factor alpha was
inhibited
Weir et al., Infect Immun 2004
(Tuberculosis) :
Mycobacterial purified protein derivatives stimulate innate immunity : Malawians show enhanced tumor necrosis factor alpha,
interleukin-1beta (IL-1beta), and
IL-10 responses compared to those of adolescents in the United Kingdom ... To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom, we examined 24-h tumor necrosis factor alpha,
interleukin-1beta (IL-1beta), and
IL-10 responses to mycobacterial purified protein derivatives ( PPDs )
Zhou et al., Mol Cell Biol 2004
:
Interleukin-10 inhibits
interleukin-12 p40 gene transcription by targeting a late event in the activation pathway
Romano et al., Clin Immunol 2005
(Acute Disease...) :
The
role of
interleukin-10 in the differential expression of
interleukin-12p70 and its beta2 receptor on patients with active or treated paracoccidioidomycosis and healthy infected subjects
Obonyo et al., FEMS Immunol Med Microbiol 2006
(Helicobacter Infections) :
Evidence for interleukin-1 independent
stimulation of
interleukin-12 and down-regulation by
interleukin-10 in Helicobacter pylori infected murine dendritic cells deficient in the interleukin-1 receptor
Good et al., J Immunol 2006
(Lupus Vulgaris) :
Stimulation of human B cells with
CD40L/IL-21 also
induced IL-10 production and activation of STAT3
Mas et al., Mult Scler 2007
(Genetic Predisposition to Disease...) :
OPN
enhances the production of the pro-inflammatory cytokines,
interleukin-12 and interferon-gamma, while reducing
interleukin-10 levels
Yin et al., J Toxicol Environ Health 2007
(Listeriosis) :
DEP or eDEP concentration-dependently suppressed L. monocytogenes
induced secretion of tumor necrosis factor-alpha,
interleukin (IL)-1beta , and IL-12 by AM and of IL-2 and interferon-gamma by lymphocytes obtained from L. monocytogenes infected rats, but augmented the AM secretion of
IL-10
Spolski et al., J Immunol 2009
:
Moreover, we show that
IL-21 signaling is
required for maximal induction of
IL-10 by IL-6 or IL-27 ... Overall, our data indicate that
IL-21 regulates immune responses at least in part by inducing
IL-10 and reveal unanticipated immunosuppressive actions for this cytokine
Buisson et al., J Infect Dis 2009
(HIV Infections) :
These functional changes may be at least partly explained by reduced
interleukin-12 and
increased interleukin-10 secretion on stimulation with lipopolysaccharide and CD40 ligand
Spolski et al., Crit Rev Immunol 2010
:
This review seeks to critically evaluate the evidence concerning the
regulation of
IL-10 by
IL-21 in a number of lineage subsets as well as to discuss the potential positive versus deleterious roles that this co-expression may play in a range of disease models
Liu et al., Cell Immunol 2011
:
In the present study, we showed that
IL-21 induced
IL-10 production by human naive CD4 ( + ) T cells
Ding et al., ACS Appl Mater Interfaces 2011
:
The inhibition of inducible nitric oxide synthase and
interleukin-1 expression and the
activation of
interleukin-10 were increased with increasing gelatin content
Nakayamada et al., Immunity 2011
:
Herein, we showed
interleukin-12 acting via the transcription factor STAT4
induced both
Il21 and Bcl6 genes, generating cells with features of both Tfh and Th1 cells
Freitas do Rosário et al., J Immunol 2012
(Inflammation...) :
Finally, in this model of malaria, we demonstrate that the generation of protective
IL10 ( + ) IFN-? ( + ) Th1 cells is dependent on IL-27 signaling and
independent of
IL-21
Newcomb et al., J Immunol 2012
(Pneumonia...) :
In this study, we extend our in vitro findings and determine that IL-13 increases IL-10 production from Th17 polarized cells and that IL-13 induced
IL-10 production negatively
regulates the secretion of IL-17A and
IL-21
Uchiyama et al., Journal of cardiothoracic surgery 2012
:
Proliferation of splenocytes,
interleukin (IL)-2 and interferon ( IFN ) -? production was suppressed in opera exposed mice, and production of IL-4 and
IL-10 from opera exposed transplant recipients
increased compared to that from splenocytes of untreated recipients
Jin et al., J Autoimmun 2013
(Inflammation) :
IL-6 induces IL-21 production in CD4 T cells and
IL-10 inducing effect of IL-6 requires both
IL-21 and IL-2
Chung et al., J Infect Dis 2013
(Leprosy, Lepromatous...) :
Galectin-3
enhanced monocyte
interleukin 10 production to a TLR2/1 ligand, whereas
interleukin 12p40 secretion was unaffected
Yang et al., PloS one 2013
(Autoimmune Diseases...) :
Here, we investigated the percentages of Tfh cells and B10 cells in lupus-prone MRL/Mp-lpr/lpr ( MRL/lpr ) mice and examined the
effects and mechanism of Tfh cell derived
interleukin-21 (IL-21) on
IL-10 production during the differentiation of B10 cells ... Tfh cell derived
IL-21 from MRL/lpr mice could
promote IL-10 production during the differentiation of B10 cells ...
IL-21 induced
IL-10 production via activation of phosphorylated signal transduction and activator of transcription 3 ( p-STAT3 ) ... Moreover,
IL-21 induced
IL-10 exerted a regulatory function by inhibiting the proliferation of T cells
Stumhofer et al., PloS one 2013
(Chronic Disease...) :
Previous studies have indicated that Il21r ( -/- ) mice chronically infected with Toxoplasma gondii display a defect in serum IgG ; however, the basis for this antibody defect was not defined and questions remain about the
role of
IL-21 in promoting the production of
IL-10 , which is required to limit infection induced pathology during toxoplasmosis
Thompson et al., J Neurotrauma 2013
(Spinal Cord Injuries) :
The best characterized
effects of
IL-10 are anti-inflammatory-it downregulates pro-inflammatory species interleukin-1ß (IL-1ß),
interleukin-2 (IL-2), interleukin-6 (IL-6), tumor necrosis factor-a, interferon-?, matrix metalloproteinase-9, nitric oxide synthase, myeloperoxidase, and reactive oxygen species
Tilg et al., Cytokine 1995
(Neoplasms) :
Induction of circulating
interleukin 10 by
interleukin 1 and interleukin 2, but not interleukin 6 immunotherapy
Benveniste et al., Proc Natl Acad Sci U S A 1996
(Acute Disease...) :
Comparative
interleukin ( IL-2 ) /interferon IFN-gamma and
IL-4/IL-10 responses during acute infection of macaques inoculated with attenuated nef truncated or pathogenic SICmac251 virus
Venkataraman et al., Cryobiology 1996
:
X. Decrease in
interleukin-12 production by frozen human peripheral blood mononuclear cells is
mediated by the endogenously hypersecreted
interleukin-10
Fulton et al., J Infect Dis 1998
:
Regulation of
interleukin-12 by
interleukin-10 , transforming growth factor-beta, tumor necrosis factor-alpha, and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra
Pai et al., Oncol Res 1998
:
Differential
effect of
interleukin 10 on
interleukin 12- and interleukin 2-mediated killer induction from blood mononuclear cells