Gene interactions and pathways from curated databases and text-mining

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CRH — IL10

Text-mined interactions from Literome

Smith et al., J Neuroimmunol 1999 : IL-10 enhances corticotropin releasing factor (CRF) and corticotropin ( ACTH ) production in hypothalamic and pituitary tissues, respectively
Cambronero et al., Regul Pept 1992 : Adrenalectomy does not change CRF secretion induced by interleukin-1 from rat perifused hypothalami
Maes et al., Neuro Endocrinol Lett 2003 : The aims of the present study were to examine i ) the effects of CRH , 10-9 M, 10 ( -8 ) M and 10 ( -7 ) M, on the stimulated production of IFNgamma, IL-10 and tumor necrosis factor-alpha (TNFalpha) by human whole blood ; and ii ) whether CRH, 10 ( -9 ) M, 10 ( -8 ) M and 10 ( -7 ) M, may antagonize some of the negative immunoregulatory effects of 5-HT, 1.5 microg/mL or 15 microg/mL
Krause et al., Horm Metab Res 2007 : alpha-Helical-CRF, a CRH antagonistic peptide, annulled the CRH effect on SZ95 sebocyte proliferation and interleukin secretion, while the non-peptidic CRH-R1 selective antagonist antalarmin inhibited the increased production of neutral lipids caused by CRH
Kageyama et al., J Endocrinol 2009 : Among them, interleukin (IL)-6 plays a role in the regulation of CRF
Oh et al., J Allergy Clin Immunol 2012 (Dermatitis, Atopic) : CRH mediated suppression of IL-10 secretion from Treg cells might explain stress related exacerbations in patients with AD
Theoharides et al., Ann Allergy Asthma Immunol 2012 (Asthma...) : CRH also reduces T-regulatory cell production of interleukin 10 , which in known to inhibit allergic mast cell activation
Sandi et al., Eur J Pharmacol 1995 : This study investigated the possibility that nitric oxide ( NO ) acts as a mediator of interleukin-1 induced CRF release ... The concurrent treatment with NG-nitro-L-arginine and indomethacin ( 14 microM ) -- an inhibitor of prostaglandin production -- reduced interleukin-1 induced CRF release to the same level as NG-nitro-L-arginine alone, suggesting that prostaglandins might interact with NO on this interleukin-1 effect
Kakucska et al., Endocrinology 1993 : Endotoxin induced corticotropin releasing hormone gene expression in the hypothalamic paraventricular nucleus is mediated centrally by interleukin-1
Dudley et al., Am J Obstet Gynecol 1999 (Obstetric Labor, Premature...) : The cytokine interleukin 1 stimulates production of corticotropin releasing hormone , and corticotropin releasing hormone in turn regulates cytokine production by immune effector cells