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ADCY4 — GNRH1

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Park et al., Endocrinology 2001 : Stage dependent regulation of ovarian pituitary adenylate cyclase activating polypeptide mRNA levels by GnRH in cultured rat granulosa cells ... The present study was designed to test whether GnRH regulates pituitary adenylate cyclase activating polypeptide mRNA levels in a stage dependent manner during follicle development in the rat ovary ... In situ hybridization analysis of cultured preovulatory follicles revealed that GnRH induced pituitary adenylate cyclase- activating polypeptide signals were detected in granulosa cells, but not thecal cells ... Taken together, these results demonstrate the stage dependent regulation of pituitary adenylate cyclase activating polypeptide mRNA levels by GnRH , the stimulatory and inhibitory effect in granulosa cells of preovulatory and immature follicles, respectively ... Interestingly, GnRH stimulated pituitary adenylate cyclase activating polypeptide mRNA levels in preovulatory granulosa cells was inhibited by arachidonyltri fluoromethyl ketone, an inhibitor of phospholipase A ( 2 ), but not by an inhibitor of protein kinase A or C. Lastly, treatment of preovulatory follicles with pituitary adenylate cyclase activating polypeptide antagonist suppressed GnRH stimulated progesterone production during 6 -- 9 h of culture
Collado et al., Int J Oncol 2004 : Thirty days after a single i.m. injection of 3 mg Cetrorelix pamoate depot to female rats, normal or ovariectomized, we evaluated the effects of this chronic treatment on the expression of alphas and alphai G-protein subunits in the ovary, breast and pituitary, as well as the adenylate cyclase response in vitro to LH-RH , vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide ( PACAP )
Matsukura et al., J Clin Endocrinol Metab 1977 (Acromegaly...) : The adenylate cyclase of a pituitary adenoma from case of Cushing 's disease was stimulated by LH-RH , norepinephrine glucagon and MEE but not by TRH
Ojeda et al., Endocrinology 1985 : The results indicate that both an increase in adenylate cyclase activity and a decrease in phosphodiesterase activity lead to LHRH release from the median eminence
Rosenthal et al., EMBO J 1988 (Pituitary Neoplasms) : In contrast to vasoactive intestinal peptide and forskolin, LHRH did not activate adenylate cyclase in membranes of GH3 cells, but rather appeared to cause inhibition of the enzyme
Urabe et al., Nihon Sanka Fujinka Gakkai Zasshi 1981 : [ Effects of gonadotropin and LHRH on the cAMP levels, adenylate cyclase and cyclic nucleotide phosphodiesterase activities in the endocrine organs of the female pubertal rabbits ( author 's transl ) ] ... Effects of gonadotropin and LHRH on the cAMP levels, adenylate cyclase and cyclic nucleotide phosphodiesterase activities of the pineal, hypothalamus, pituitary, adrenal and ovary of the female pubertal rabbits were examined, and serum FSH, LH, estradiol and progesterone were measured
Dorflinger et al., Endocrinology 1984 : Both prostaglandin F2 alpha ( PGF2 alpha ) and LHRH inhibit LH-stimulated cAMP accumulation and progesterone secretion in the intact luteal cell, but have no effect on LH-sensitive adenylate cyclase activity in isolated membranes
Théoleyre et al., Mol Cell Endocrinol 1976 : To explain these results, it may be argued that the proportion of gonadotrophs in the pituitary gland is too small to show a significant increase in the LH-RH induced adenylate cyclase activity