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GATA1 — KLF1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Hou et al., Cell Res 2008
:
The combined data demonstrate that Sp1/Sp3, but not
EKLF , is
involved in the activation of the
GATA-1 erythroid promoter, and that histones H3 and H4 are highly acetylated in this promoter region for an actively transcribed GATA-1 gene in K562 cells in which EKLF is barely detectable
Amaya et al., Blood 2013
:
We show that independent of MBD2-NuRD and
GATA-1/FOG-1/NuRD , Mi2ß binds directly to and positively
regulates both the
KLF1 and BCL11A genes, which encode transcription factors critical for ?-globin gene silencing during ß-type globin gene switching
Crossley et al., J Biol Chem 1994
:
Regulation of the
erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor
GATA-1 ... The
EKLF promoter can be directly
activated in nonerythroid cells in cotransfection experiments by forced expression of
GATA-1 ... These results suggest that
EKLF is
dependent on
GATA-1 for its expression and lies downstream of, or coincident with, GATA-1 in a regulatory hierarchy in erythroid development