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FOXO3 — PPP2R1A

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: PPP2R1A — FOXO3 (association, coimmunoprecipitation) Singh et al., Mol Biol Cell 2010*
• IRef Intact Interaction: Complex of PPP2R1A-PPP2CA-FOXO3-PPP2CB (association, tandem affinity purification) Singh et al., Mol Biol Cell 2010*

Text-mined interactions from Literome

Yin et al., J Neurosci 2006 : Suppression of PP2A activity by RNA interference or a specific inhibitor, okadaic acid, effectively suppressed Abeta induced Akt inactivation and FKHRL1 activation, leading to an attenuation of bim expression and cell death in CECs
Ni et al., Proc Natl Acad Sci U S A 2007 (Insulin Resistance) : In addition, FoxO activity suppresses protein phosphatase 2A (PP2A) and disrupts Akt-PP2A and Akt-calcineurin interactions
Bertoli et al., Oncogene 2009 (Starvation) : PP2A associates more tightly with Akt in CAPNS1 knockout cells, indicating that PP2A is involved in calpain mediated FoxO regulation
Liu et al., Cell death & disease 2012 (Listeriosis) : PP2A dependent control of transcriptionally active FOXO3a in CD8 ( + ) central memory lymphocyte survival requires p47(phox)