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FOXO3 — PINK1

Text-mined interactions from Literome

Mei et al., Proc Natl Acad Sci U S A 2009 : FOXO3a dependent regulation of Pink1 ( Park6 ) mediates survival signaling in response to cytokine deprivation ... Here we report that the FOXO family member FOXO3a controls Pink1 transcription in both mouse and human cells subjected to growth factor deprivation and that this regulation is exerted through evolutionarily conserved FOXO binding elements ... Induction of Pink1 by FOXO3a is crucial for survival signals in lymphocytes, as depletion of Pink1 sensitizes these cells to death induced by deprivation of an essential growth factor
Koh et al., J Biol Chem 2012 (Disease Models, Animal...) : Consistent with its mitochondria protecting role, Sir2 expression prevented the DA neuron loss of PINK1 null mutants in a FOXO dependent manner