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ANG — EGF
Text-mined interactions from Literome
Uemura et al., Nihon rinsho. Japanese journal of clinical medicine 2005
(Prostatic Neoplasms) :
Our previous study demonstrated that
Angiotensin II (Ang-II) which is well known to be a main peptide of the renin-angiotensin system could
activate the cell proliferation of prostate cancer as well as
EGF , and an Ang-II receptor blocker(ARB) could inhibit it through the suppression of phosphorylation of MAPK and STAT3
Dewachter et al., Am J Respir Crit Care Med 2006
(Hyperplasia...) :
Ang1 added to P-ECs from patients with iPAH
increased the production of endothelin-1 (ET-1) and serotonin, but not of platelet derived growth factor-BB or
epidermal growth factor , and increased the amount of mRNA encoding tryptophan hydroxylase-1 ( the rate limiting enzyme of serotonin synthesis ), preproET-1, and ET-1 converting enzyme
Akhtar et al., Br J Pharmacol 2012
(Body Weight...) :
Here, we investigated whether
Ang- ( 1-7 ) can
inhibit hyperglycaemia induced
EGF receptor transactivation and its classical signalling via ERK1/2 and p38 MAPK in vivo and in vitro ... Streptozotocin induced diabetic rats were chronically treated with
Ang- ( 1-7 ) or AG1478, a selective
EGF receptor
inhibitor , for 4 weeks and mechanistic studies performed in the isolated mesenteric vasculature bed as well as in primary cultures of vascular smooth muscle cells ( VSMCs ) ... These results show for the first time that
Ang- ( 1-7 )
inhibits EGF receptor transactivation via a Mas receptor/Src dependent pathway and might represent a novel general mechanism by which Ang- ( 1-7 ) exerts its beneficial effects in many disease states including diabetes induced vascular dysfunction