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CTNNB1 — SRC

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CTNNB1 → SRC (increases, CTNNB1 Activity)
  Evidence: The rates of oxidative stress-induced activation of c-Src, tyrosine phosphorylation of ZO-1 and beta-catenin, decrease in resistance, increase in permeability to inulin, and redistribution of occludin and ZO-1 were significantly greater in cells transfected with wild type c-Src, whereas it was low in cells transfected with kinase-inactive c-SrcK297R mutant, when compared with those in empty vector-transfected cells.
• KEGG Adherens junction: SRC → CTNNB1 (protein-protein, inhibition)
• NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly: Src (SRC) → E-cadherin/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1) (modification, activates)
  Fujita et al., Nat Cell Biol 2002, Palacios et al., Mol Cell Biol 2005
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly: Src (SRC) → E-cadherin/beta catenin complex (CDH1-CTNNB1) (modification, activates)
  Fujita et al., Nat Cell Biol 2002, Palacios et al., Mol Cell Biol 2005
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): E-cadherin/beta catenin/alpha cateninNUMB/Par3/Par6/Atypical PKCs complex (CDH1-NUMB-CTNNB1-CTNNA1-F2RL2-PARD6A-PRKCI_PRKCZ) → Src (SRC) (modification, collaborate) Wang et al., EMBO J 2009
  Evidence: physical interaction
• NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly: Src (SRC) → E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1) (modification, activates)
  Roura et al., J Biol Chem 1999, Piedra et al., J Biol Chem 2001, Fujita et al., Nat Cell Biol 2002, Duchesne et al., J Biol Chem 2003, Simoneau et al., Cell Signal 2011
  Evidence: assay, physical interaction
• NCI Pathway Database E-cadherin signaling in keratinocytes: E-cadherin/beta catenin-gamma catenin complex (CDH1-CTNNB1_JUP) → Src (SRC) (modification, collaborate) Xie et al., Mol Biol Cell 2005, Calautti et al., J Cell Biol 1998
  Evidence: assay, physical interaction, other species
• NCI Pathway Database E-cadherin signaling in keratinocytes: Src (SRC) → E-cadherin/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1) (modification, activates)
  Xie et al., Mol Biol Cell 2005, Calautti et al., J Cell Biol 1998
  Evidence: assay, physical interaction, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• MIPS CORUM Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1): Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) complex (ACTN1-BCAR1-CDH1-CTNNB1-JUP-PKD1-PTK2-PXN-SRC-TLN1-VCL) Geng et al., Biochim Biophys Acta 2000
• IRef Corum Interaction: Complex of 12 proteins (association, cosedimentation through density gradient) Geng et al., Biochim Biophys Acta 2000
• IRef Dip Interaction: SRC — CTNNB1 (direct interaction, protein kinase assay) Yang et al., Nature 2011*
• IRef Dip Interaction: SRC — CTNNB1 (direct interaction, anti bait coimmunoprecipitation) Yang et al., Nature 2011*
• IRef Hprd Interaction: SRC — CTNNB1 (in vitro) Piedra et al., J Biol Chem 2001

Text-mined interactions from Literome

Li et al., J Biol Chem 2001 : The findings support a novel role for c-Src in regulating interactions of MUC1 with GSK3 beta and beta-catenin
Farkas et al., J Neurosci Res 2005 : Hyperosmotic mannitol induces Src kinase dependent phosphorylation of beta-catenin in cerebral endothelial cells
Karni et al., Mol Cell Biol 2005 : Activated Src enhances the accumulation of nuclear beta-catenin and enhances its transcriptional activity, elevating target genes such as cyclin D1
Coluccia et al., Cancer Res 2006 (Colorectal Neoplasms) : SKI-606 decreases growth and motility of colorectal cancer cells by preventing pp60(c-Src) dependent tyrosine phosphorylation of beta-catenin and its nuclear signaling ... Src dependent activation of beta-catenin was prevented by SKI-606, a novel Src family kinase inhibitor, which also abrogated beta-catenin nuclear function by impairing its binding to the TCF4 transcription factor and its trans activating ability in colorectal cancer cells
Chen et al., Cancer Lett 2008 : An acidic extracellular pH induces Src kinase dependent loss of beta-catenin from the adherens junction ... The acidic pHe induced c-Src activation increased tyrosine phosphorylation of beta-catenin and decreased the amount of beta-catenin associated E-cadherin
Inge et al., Mol Cancer Ther 2008 : alpha-Catenin overrides Src dependent activation of beta-catenin oncogenic signaling ... Further, Src mediated tyrosine phosphorylation of beta-catenin is a major mechanism for decreased beta-catenin interaction with E-cadherin in alpha-catenin-null cells
Chang et al., Oncogene 2008 (Prostatic Neoplasms) : Src inhibition resulted in decreased binding of beta-catenin to the promoters of G1 phase cell cycle regulators cyclin D1 and c-Myc
Desprat et al., Dev Cell 2008 : We find that stomodeal compression triggers Src42A dependent nuclear translocation of Armadillo/beta-catenin , which is required for Twist mechanical induction in the stomodeum
Chen et al., J Cell Biochem 2009 : We have previously shown that culturing HepG2 cells in pH 6.6 culture medium increases the c-Src dependent tyrosine phosphorylation of beta-catenin and induces disassembly of adherens junctions ( AJs )
Zhang et al., Blood 2009 (MAP Kinase Signaling System) : Src can directly interact with beta-catenin and trigger nuclear translocation of beta-catenin