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CCR6 — CCR7

Pathways - manually collected, often from reviews:

• Reactome Reaction: CCR6 → CCR7 (reaction) Lerea et al., Neuron 1989, Van Dop et al., Nucleic Acids Res 1989, Itoh et al., J Biol Chem 1988, Takami et al., Brain Res Mol Brain Res 1994

Text-mined interactions from Literome

Sato et al., J Immunol 2000 : Stimulation of mature DCs with TGF-beta 1 also enhanced TNF-alpha induced down-regulation of the expressions of CCR-1, CCR-3, CCR-5, CCR-6 , and CXCR-4, and chemotaxis to their respective ligands, while this stimulation suppressed TNF-alpha induced expression of CCR-7 and chemotactic migratory ability to MIP-3 beta
Iwasaki et al., J Exp Med 2000 : These data support a distinct role for MIP-3alpha/CCR6 in recruitment of CD11b ( + ) DCs toward the mucosal surfaces and for MIP-3beta/CCR7 in attraction of CD8alpha ( + ) DCs to the T cell regions
Dieu et al., J Exp Med 1998 : Finally, detection by in situ hybridization of MIP-3alpha mRNA only within inflamed epithelial crypts of tonsils, and of MIP-3beta mRNA specifically in T cell-rich areas, suggests a role for MIP-3alpha/CCR6 in recruitment of immature DCs at site of injury and for MIP-3beta/CCR7 in accumulation of antigen loaded mature DCs in T cell-rich areas