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BDNF — HTT
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Zuccato et al., Science 2001
(Huntington Disease...) :
Loss of
huntingtin mediated
BDNF gene transcription in Huntington 's disease
Canals et al., J Neurosci 2004
(Ataxia...) :
Brain derived neurotrophic factor (BDNF) protects striatal neurons and is
regulated by
Huntingtin through the interaction with the neuron-restrictive silencer factor
del Toro et al., J Neurosci 2006
(Huntington Disease) :
Moreover, mutant
huntingtin severely
affected the KCl evoked release of
Val-BDNF , although it had little effect on Met-BDNF regulated release ... We conclude that mutant
huntingtin differently
affects intracellular transport and release of
Val-BDNF and Met-BDNF
Zuccato et al., J Neurosci 2007
(Genetic Predisposition to Disease...) :
We first reported that wild-type
huntingtin positively
affects the transcription of the
brain derived neurotrophic factor (BDNF) gene, a cortically derived survival factor for the striatal neurons that are mainly affected in the disease
Samadi et al., Genes, brain, and behavior 2013
(Disease Models, Animal...) :
Mutant
huntingtin protein expression in R6/2 mice
results in progressive loss of
BDNF in both cortical and subcortical striatal afferents
Giampà et al., PloS one 2013
:
Loss of
huntingtin mediated
BDNF gene transcription has been shown to occur in HD and thus contribute to the degeneration of the striatum