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BCR — CD40

Text-mined interactions from Literome

Qi et al., Proc Natl Acad Sci U S A 2003 : Rapid activation of CTCF by BCR ligation or treatment with TGF-beta was suppressed by ligation of CD40
Hokazono et al., J Immunol 2003 : Ag-induced B cell proliferation in vivo requires a costimulatory signal through CD40, whereas B cell Ag receptor (BCR) ligation by anti-Ig H chain Abs, such as anti-Ig micro H chain Ab and anti-Ig delta H chain Ab, alone induces proliferation of B cells in vitro, even in the absence of CD40 ligation
Masilamani et al., Eur J Immunol 2003 : CD21 shedding is induced by stimulation with PMA plus Ca ( 2+ ) ionophore, or by stimulation of the BCR with anti-IgM+anti-CD40
Hillion et al., J Immunol 2007 : In previous studies, we demonstrated that cross linking the BCR and the CD40 induces the expression of the RAG1 and RAG2 enzymes and, thereby, secondary rearrangements
Henry et al., J Immunol 2009 (Calcium Signaling) : These include BCR down-regulation, impaired proliferative responses to anti-CD40 , and diminished calcium mobilization upon stimulation with BCR dependent and independent stimuli
Man et al., PloS one 2010 : Both BCR signaling defect and augmented response to CD40 ligation are partially restored in xid IgG-transgenic mice in which BCR signaling is down modulated due to a loss-of-function mutation in the tyrosine kinase Btk crucial for BCR signaling
Ying et al., Immunobiology 2011 : It has been shown that CD40 stimulation can augment BCR induced B cell responses, but the molecular mechanism ( s ) by which CD40 regulates BCR signaling is poorly understood
Mullins et al., Mol Immunol 1998 : Finally, CD40 mediated signals induce resting B cells to accumulate the CKI, p21, while cycling B cells require both BCR- and CD40 mediated signals to maintain increased expression of p21