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AKT2 — HDAC6
Text-mined interactions from Literome
De Sarno et al., Neuropharmacology 2002
:
Two other inhibitors of
histone deacetylase , a recently identified target of sodium valproate, also
caused gradual increases in the phosphorylation of
Akt and GSK3beta
Bali et al., J Biol Chem 2005
(Leukemia) :
Conversely, the ectopic overexpression of
HDAC6 inhibited LAQ824 induced acetylation of HSP90 and alpha-tubulin and
reduced LAQ824 mediated depletion of Bcr-Abl,
AKT , and c-Raf
Chen et al., J Biol Chem 2005
:
Histone acetylation independent
effect of
histone deacetylase inhibitors on
Akt through the reshuffling of protein phosphatase 1 complexes
Lee et al., Mol Pharmacol 2008
:
Finally, activation of
Akt and CaM kinase II may eventually
lead to the acetylation of histone residues and phosphorylation of
histone deacetylase
Kim et al., Radiother Oncol 2009
(Neoplasms) :
Conversely, ectopic overexpression of
HDAC6 isotype
increased the levels of p-EGFR and
p-AKT expression, and reduced LBH589 mediated radiosensitization
Moskowitz et al., Curr Oncol Rep 2012
(Hodgkin Disease) :
Additional agents that have demonstrated activity in HL include
histone deacetylase inhibitors, such as panobinostat, entinostat, and mocetinostat,
PI3-kinase/Akt/Mtor pathway
inhibitors , such as everolimus, as well as lenalidomide and bendamustine