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AKT2 — GRK5

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: GRK5 — AKT2 (physical association, affinity chromatography technology) Wu et al., PloS one 2012

Text-mined interactions from Literome

Kurose et al., Nihon Yakurigaku Zasshi 1999 (Myocardial Reperfusion Injury) : Expression of GRK2-ct inhibited the H2O2 induced activation of ERK by 70 % and also inhibited the activation of Akt by 30 %
Liu et al., Nat Med 2005 (Hypertension, Portal) : Furthermore, GRK2 expression increased in sinusoidal endothelial cells from portal hypertensive rats and knockdown of GRK2 restored Akt phosphorylation and NO production, and normalized portal pressure
Zhou et al., Clinical and translational science 2009 : GRK5 overexpression in HCAECs significantly suppressed both acute and late activation of Akt and extracellular signal related kinase ( ERKs ) as well as the phosphorylation of GSK-3beta, an endogenous substrate of Akt
Zheng et al., Proc Natl Acad Sci U S A 2012 : By suppressing GRK expression with siRNA, we demonstrated that lowering GRK5/6 abolishes IGF1 mediated ERK and AKT activation, whereas GRK2 inhibition increases ERK activation and partially inhibits AKT signaling