Shen et al., J Am Soc Nephrol 2006
:
Expression of a constitutively active Akt increased GAPDH and pax2 abundance
Huang et al., J Biol Chem 2011
(Ovarian Neoplasms) :
This effect of Akt2 is partly mediated by its phosphorylation of GAPDH at Thr-237, which results in the inhibition of GAPDH nuclear translocation
Yao et al., J Cell Physiol 2012
(Starvation) :
Inhibition of Akt prevented PE-induced GAPDH activity increase and cardiomyocytes protection
Leisner et al., Oncogene 2013
(MAP Kinase Signaling System...) :
In defining each pathway 's contributions, we found that AKT inhibition alone maximally induced GAPDH nuclear accumulation, whereas MEK/ERK inhibition alone had no effect on GAPDH localization