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ABL1 — XRCC6

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: XRCC6 — ABL1 (physical association, affinity chromatography technology) Kumaravel et al., Int J Radiat Biol 1998*
• IRef Hprd Interaction: XRCC6 — ABL1 (in vivo) Kumaravel et al., Int J Radiat Biol 1998*
• IRef Ophid Interaction: XRCC6 — ABL1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: XRCC6 — ABL1 (aggregation, confirmational text mining) Kumaravel et al., Int J Radiat Biol 1998*

Text-mined interactions from Literome

Shangary et al., J Biol Chem 2000 (Ataxia Telangiectasia) : To unravel the role of ATM and DNA-PK in the activation of Abl , we assayed Abl, ATM, and DNA-PK activity in ATM- and DNA-PKcs-deficient cells after irradiation ... Conversely, normal activation of both ATM and c-Abl occurs in DNA-PKcs-deficient cells, indicating that ATM but not DNA-PK is required for activation of Abl in response to IR treatment ... Examination of DNA-PK activity in response to IR treatment in Abl-deficient cells expressing mutant forms of Abl or in normal cells exposed to an inhibitor of Abl suggests an in vivo role for Abl in the down-regulation of DNA-PK activity
Mizuchi et al., Biochem Biophys Res Commun 2005 : BCR/ABL activates Rap1 and B-Raf to stimulate the MEK/Erk signaling pathway in hematopoietic cells ... Here we demonstrate that the inducible expression of BCR/ABL in a murine hematopoietic cell line, TonB210, leads to the activation of the Ras family small GTPase Rap1 , which is inhibited by the ABL kinase inhibitor imatinib
Nolz et al., J Cell Biol 2008 : The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G mediated activation of Rap1
Tang et al., Chembiochem 2012 : Our findings show that nuclear and cytoplasmic Abl kinase is activated early on ( within 5 min ) in response to IR by both ATM and DNAPK , and that although one or the other of these kinases is required, either one is sufficient to activate Abl
Kharbanda et al., Nature 1997 : We show that DNA-PK phosphorylates and activates c-Abl in vitro
Kharbanda et al., Oncogene 1998 : The DNA dependent protein kinase (DNA-PK) and the ataxia telangiectasia mutated (ATM) gene product, effectors in the DNA damage response, contribute to the induction of c-Abl activity
Kharbanda et al., Oncogene 1998 : c-Abl associates with the DNA dependent protein kinase (DNA-PK) and is activated by DNA-PK dependent phosphorylation