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SOX17 — WNT6
Text-mined interactions from Literome
Fu et al., Breast Cancer Res Treat 2010
(Breast Neoplasms) :
These findings indicate that silencing of
Sox17 due to promoter hypermethylation is a frequent event and may
contribute to aberrant activation of
Wnt signaling in breast cancer
Du et al., Gastroenterology 2009
(Cell Transformation, Neoplastic...) :
Sox17 represses
Wnt/beta-catenin signaling and is down-regulated in colon cancer ...
Sox17 was
induced in K19-Wnt1/C2mE mouse gastric tumors and K19-Wnt1 preneoplastic lesions, where
Wnt/beta-catenin signaling was activated ... Consistently,
Wnt activation
induced Sox17 expression in gastric cancer cells ... However, Sox17 is induced by
Wnt activation in the early stage of gastrointestinal tumorigenesis, and
Sox17 is
down-regulated by methylation during malignant progression
Kormish et al., Dev Dyn 2010
(Neoplasms) :
In some contexts,
Wnt signaling also
regulates SOX expression resulting in feedback regulatory loops that fine-tune cellular responses to beta-catenin/TCF activity
Wang et al., J Biol Chem 2013
(Breast Neoplasms...) :
Consistently,
SOX9 overexpression in BCa cell lines and transgenic SOX9 expression in breast epithelium
caused increased LRP6 and TCF4 expression and
Wnt/ß-catenin activation
Chen et al., Cancer Lett 2013
(Oligodendroglioma...) :
These changes were associated with increased SFRP1, and reduced expression of Wnt-1 and Frizzled-1, -3 and -7 RNA, indicating that
Sox17 induced a Hedgehog target, and
regulated Wnt signaling at multiple levels