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TBK1 — TRAF6
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
TRAF6
→
TBK1
(indirect_complex)
Pomerantz et al., EMBO J 1999, Chariot et al., J Biol Chem 2002, Konno et al., PloS one 2009
-
Reactome Reaction:
TRAF6
→
TBK1
(reaction)
Pomerantz et al., EMBO J 1999, Chariot et al., J Biol Chem 2002, Paz et al., Cell Mol Biol Incl Cyto Enzymol 2006, Konno et al., PloS one 2009
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Sato et al., J Immunol 2003
:
Because TRAF6 and TBK1 bind close the region of TRIF, it seems that
TRAF6 physically
prevents the association between TRIF and
TBK1
Qu et al., Mol Cell Biol 2012
:
TRAF6 was
essential for IL-17 induced
TBK1 activation, its association with Act1, and consequent Act1 phosphorylation