◀ Back to BMP2
BMP2 — SOSTDC1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database BMP receptor signaling:
USAG1 (SOSTDC1)
→
BMP2-4 (homodimer) complex (BMP4_BMP2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
USAG1 (SOSTDC1)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
USAG1 (SOSTDC1)
→
BMP2-4/USAG1 complex (BMP4_BMP2-SOSTDC1)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMP2-4/USAG1 complex (BMP4_BMP2-SOSTDC1)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
→
BMP2-4/USAG1 complex (BMP4_BMP2-SOSTDC1)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BMP2-4/USAG1 complex (BMP4_BMP2-SOSTDC1)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
RGM family (RGMB/RGMA/HFE2)
→
BMP2-4/USAG1 complex (BMP4_BMP2-SOSTDC1)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMPR2 (homodimer) complex (BMPR2)
→
BMP2-4/USAG1 complex (BMP4_BMP2-SOSTDC1)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BAMBI (BAMBI)
→
BMP2-4/USAG1 complex (BMP4_BMP2-SOSTDC1)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
→
BMP2-4/USAG1 complex (BMP4_BMP2-SOSTDC1)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Laurikkala et al., Dev Biol 2003
:
Ectodin inhibited the activity of BMP2, BMP4,
BMP6 , and BMP7 for mouse preosteoblastic MC3T3-E1 cells, and bound to these BMPs with high affinity ...
BMP2 and BMP7
stimulated ectodin expression in tooth explants, showing that it is part of a feedback mechanism controlling the activity of BMPs ... The
stimulation of
ectodin expression by
BMP was prevented by SHH and FGF4 but not by Wnt6
Kassai et al., Science 2005
:
We report that
ectodin , a secreted
bone morphogenetic protein ( BMP ) inhibitor , is expressed as a `` negative '' image of mouse enamel knots
Wu et al., J Clin Invest 2008
(Cleft Palate) :
Furthermore, we demonstrated that Pax3 directly regulates expression of
Sostdc1 , a soluble
inhibitor of
bone morphogenetic protein ( BMP ) signaling
Clausen et al., Breast Cancer Res Treat 2011
(Breast Neoplasms) :
SOSTDC1 differentially
affects Wnt3a,
BMP-2 , and BMP-7 signaling in breast cancer cells
Henley et al., Am J Physiol Endocrinol Metab 2012
(Glucose Intolerance...) :
Loss of
Sostdc1 in the setting of metabolic stress
results in altered expression of
Bmp-responsive genes in islets but did not affect expression of Wnt target genes, suggesting that Sostdc1 primarily regulates the Bmp pathway in the murine pancreas ... Furthermore, our data indicate that removal of
Sostdc1 enhances the downregulation of the closely related
Bmp inhibitors Ctgf and Gremlin in islets after 8-wk exposure to high-fat diet