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TNF — WDR1

Text-mined interactions from Literome

Zhang et al., J Clin Invest 2003 (MAP Kinase Signaling System) : AIP1 exists in a closed form through an intramolecular interaction between the N-terminus and the C-terminus, and TNF-alpha induces unfolding of AIP1 leading to association of AIP1 with ASK1
Zhang et al., J Biol Chem 2004 : TNF binding induces release of AIP1 from TNFR1, resulting in cytoplasmic translocation and concomitant formation of an intracellular signaling complex comprised of TRADD, RIP1, TRAF2, and AIPl
Zhang et al., J Biol Chem 2007 (MAP Kinase Signaling System) : In the present study, we show that a TNF-inducible 14-3-3 binding site on AIP1 is critical for the opening of its conformation and for the AIP1 mediated TNF signaling ... TNF treatment of EC induces phosphorylation of AIP1 at Ser-604 as detected by a phospho-specific antibody, with a similar kinetics to ASK1-JNK/p38 activation ... TNF treatment normally induces association of AIP1 with TRAF2-ASK1 ... We further show that RIP1 ( the Ser/Thr protein kinase receptor interacting protein ) associates with the GAP domain of AIP1 and mediates TNF induced AIP1 phosphorylation at Ser-604 and JNK/p38 activation as demonstrated by both overexpression and small interfering RNA knockdown of RIP1 in EC ... Our results demonstrate that RIP1 mediated AIP1 phosphorylation at the 14-3-3 binding site Ser-604 is essential for TNF induced TRAF2-RIP1-AIP1-ASK1 complex formation and for the activation of ASK1-JNK/p38 apoptotic signaling
Min et al., Circ Res 2008 : Endogenous AIP1-PP2A complex can be detected in the resting state, and TNF induces a complex formation of AIP1-PP2A with ASK1