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IL4 — TNF

Text-mined interactions from Literome

Luttmann et al., Am J Respir Cell Mol Biol 1999 : However, eosinophil viability and CD69 expression increased synergistically when eosinophils were incubated with IL-13 or IL-4 in the presence of TNF-alpha
Alaaeddine et al., Arthritis Rheum 1999 (Osteoarthritis) : IL-4 had no effect on TNFalpha up-regulation of NF-kappaB, and a slight decrease was noted with IL-10 and IL-13 at the highest concentration used ( 5 ng/ml )
Levings et al., J Immunol 1999 : IL-4 inhibits the production of TNF-alpha and IL-12 by STAT6 dependent and -independent mechanisms ... We report here that the inhibitory effects of IL-4 on the production of TNF-alpha or IL-12 by macrophages had both STAT6 dependent and -independent components, depending on the stimuli ... However, IL-4 still induced significant inhibition of the production of TNF-alpha and IL-12 from STAT6 null macrophages that were stimulated with the more physiologically relevant combination of LPS and IFN-gamma ... These data show that STAT6 is required for the IL-4 mediated inhibition of the production of TNF-alpha and IL-12 stimulated by LPS alone, but that IL-4 also activates distinct, STAT6 independent mechanism(s) that inhibit the IFN-gamma mediated enhancement of IL-12 and TNF-alpha production
Bonder et al., Immunology 1999 (Arthritis, Rheumatoid) : Similarly, IL-4 can not suppress LPS induced tumour necrosis factor-alpha (TNF-alpha) production by synovial fluid cells and monocyte derived macrophages ... The failure of IL-4 to regulate IL-10 production is not due to the failure of IL-4 to suppress TNF-alpha , and vice versa
Larsson et al., Br J Pharmacol 1999 : IL-2 and IL-4 counteract budesonide inhibition of GM-CSF and IL-10, but not of IL-8, IL-12 or TNF-alpha production by human mononuclear blood cells
Hildner et al., Clin Exp Immunol 1999 (Arthritis, Rheumatoid) : Interestingly, MTX did not enhance IL-4 production when present during restimulation of effector CD45RO T cells, although it still suppressed TNF production
Tormey et al., Clin Exp Immunol 2000 (Asthma) : Fluticasone also reversed the increase in both D1+ expression and TNF-alpha production induced by IL-4
De Caterina et al., Am J Clin Nutr 2000 (Arteriosclerosis) : Consumption of the n-3 fatty acid docosahexaenoic acid ( DHA ; 22 : 6n-3 ) reduced endothelial expression of vascular cell adhesion molecule 1 ( VCAM-1 ), E-selectin, intercellular adhesion molecule 1 ( ICAM-1 ), interleukin 6 (IL-6), and IL-8 in response to IL-1, IL-4, tumor necrosis factor , or bacterial endotoxin, with a half-maximal inhibitory concentration ( IC ( 50 ) ) of 1-25 micromol, ie, in the range of nutritionally achievable plasma concentrations
Trindade et al., J Orthop Res 1999 : Interleukin-4 inhibits granulocyte-macrophage colony stimulating factor, interleukin-6, and tumor necrosis factor-alpha expression by human monocytes in response to polymethylmethacrylate particle challenge in vitro ... Interleukin-4 inhibited the expression of granulocyte-macrophage colony stimulating factor, interleukin-6, and tumor necrosis factor-alpha at 48 hours in a dose dependent manner
Morris et al., J Immunol 2000 : We examined the possibilities that IL-4 stimulation of IFN-gamma production, suppression of IL-1 or IL-2 production, or induction of TNF-alpha or Fas mediated apoptosis could account for IL-4 's suppressive effect
Ledeboer et al., Glia 2000 : IL-10 ( 10 and 100 ng/ml ) and IL-4 ( 5 and 50 U/ml ) suppressed the LPS induced production of NO, IL-6, and TNF-alpha in a dose dependent manner, whereas TGF-beta1/beta2 ( 2 and 20 ng/ml ) only suppressed NO production
Hiromatsu et al., J Clin Endocrinol Metab 2000 (Graves Disease) : IFNgamma, TNFalpha , IL-1beta, and IL-6 messenger RNA ( mRNA ) were mainly detected in EM tissue, whereas IL-4 and IL-10 mRNA were detected in only one patient
Aleman et al., Scand J Immunol 2000 (Leprosy) : So, the inhibitory effect of IL-4 on either production of IFN-gamma, TNF-alpha and/or IL-12 or their receptors could be the mechanism underlying the lack of the hsp65 CTL generation in cells from MB
Paludan et al., Arch Virol 2000 : IL-4 reduced virus induced TNF-alpha secretion and nuclear factor (NF)-kappaB activation significantly, but less in cells concomitantly treated with IFN-gamma
Giampietri et al., Cytokine 2000 (Disease Models, Animal...) : Dual effect of IL-4 on resistance to systemic gram negative infection and production of TNF-alpha
Harris et al., Prostate 2000 (Disease Models, Animal...) : After 4 weeks of treatment with E ( 2 ) + DHT, a significant increase in transcript levels of IL-4 , IL-5, IL-6, MIP-2, eotaxin, and iNOS was detected , while IL-1beta and TNF-alpha transcript levels only increased slightly
Hernandez-Pando et al., Immunology 2000 (Hypersensitivity, Delayed...) : This progressive phase is accompanied by increasing expression of IL-4 , and diminished expression of IL-1 and TNF-alpha
Newton et al., Infect Immun 2000 (Legionnaires' Disease) : Thus, the lack of IL-4 in the deficient mice resulted in unchecked TNF-alpha production, which appeared to cause the mortality ... However, MCP-1 did not appear to be induced by IL-4 or to be required for the TNF-alpha regulation by IL-4
Tsai et al., Life Sci 2000 : Production of tumor necrosis factor (TNF)-alpha and IL-1beta by mouse mesangial cells was not blocked by SSA but production of IL-4 by these cells was inhibited by it ( > 0.1 mM )
Sobel et al., Diabetologia 2000 (Diabetes Mellitus, Type 1) : Cyclophosphamide treatment decreased IL-12, IL-1beta, IL-2, IFN-gamma and TNF-alpha gene expressions in mononuclear spleen cells but IL-4 gene expression increased
Latijnhouwers et al., Arch Dermatol Res 2000 (Carcinoma, Basal Cell...) : In contrast, TNF alpha favoured expression of smaller tenascin-C transcripts, and IL-4 equally affected the expression of large and small tenascin-C mRNAs
Ghigo et al., Infect Immun 2001 (Endocarditis, Bacterial...) : First, interleukin-10 suppressed C. burnetii stimulated production of TNF
Amjad et al., Ir J Med Sci 2001 (Helicobacter Infections) : Inhibitory effect of IL-4 on the production of IL-1 beta and TNF-alpha by gastric mononuclear cells of Helicobacter pylori infected patients
Im et al., J Biomed Mater Res 2001 (Inflammation) : Enzyme linked immunosorbent assay and reverse transcription-polymerase chain reaction showed that both IL-4 and IL-10 significantly reduced the production of TNF-alpha and IL-6 ... IL-4 had more consistent suppressive effect on TNF-alpha production
Wei et al., J Biol Chem 2002 (MAP Kinase Signaling System) : IL-4 also selectively inhibits TNF signaling, while enhancing that of IL-1
Matejuk et al., J Neurosci Res 2002 (Encephalomyelitis, Autoimmune, Experimental) : Of note, we present evidence that TNF-alpha may be involved in regulating RANTES and MIP-1alpha, and that IL-4 may be involved in regulating MCP-1
He et al., J Rheumatol 2002 (Osteoarthritis) : The antiinflammatory cytokine IL-4 blocked LTB4 dependent stimulation of IL-1beta and TNF-alpha synthesis
Brodbeck et al., J Lab Clin Med 2002 (Foreign-Body Reaction) : We found that TNF-alpha induces apoptosis in a time- and dose dependent manner, whereas IL-4 inhibits TNF-alpha induced and spontaneous apoptosis of biomaterial-adherent macrophages
Hensel et al., Cytotherapy 2002 : CMV stimulation induced tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) in both CD4 ( + ) and CD8 ( + ) cells ( usually together ), with a shift from memory- to effector-cell phenotype, while only a small proportion of CD4 ( + ) cells produced IL-4
Bonder et al., Cytokine 2002 : While IL-4 can suppress LPS induced interleukin beta ( IL-beta ) and tumour necrosis factor alpha (TNF-alpha) production by monocytes, IL-4 can suppress LPS induced IL-1 beta, but not TNFalpha production by the more differentiated cells ... Like MDMac, interferon alpha ( IFNalpha ) -treated monocytes expressed less IL-4 receptor gamma c chain, reduced levels of IL-4 activated STAT6 and IL-4 could not suppress LPS induced TNFalpha production
Wirjatijasa et al., J Neurosci Res 2002 : The LPS induced secretion of IL-1beta and TNF-alpha was only reduced after application of ACM, whereas IL-4 or IL-10 did not inhibit IL-1beta- or TNF-alpha secretion
McDyer et al., J Immunol 2002 : HAT partially inhibited production of TNF-alpha and completely inhibited production of IL-4 , IL-5, and IL-10
Schmit et al., Eur Cytokine Netw 2002 (Crohn Disease) : The in vitro model we used, demonstrates that IL-4 , but mostly IL-10, efficiently suppresses TNF-alpha secretion in LPMNC from CD patients, with a dose-response curve similar to results obtained in vivo
Lutz et al., J Immunol 2002 : In contrast, the production of IL-12 p70, but not IL-10 and TNF , induced by microbial products was enhanced only by IL-4 , not by IL-13 or Y119D, a selective type II IL-4R agonist, in vitro and in vivo
Saubermann et al., Inflamm Bowel Dis 2002 (Acute Disease...) : The reduction in DSS induced inflammation noted with PPARgamma ligand treatment was associated with decreased interferon-gamma and tumor necrosis factor-alpha and increased interleukin (IL)-4 and IL- 10 levels as assessed by quantitative reverse transcriptase-polymerase chain reaction
Werth et al., J Invest Dermatol 2003 : Although interleukin-12 is considered to act primarily on lymphocytes, provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha, we hypothesized that interleukin-12 might also affect tumor necrosis factor alpha secretion from skin cells ... Remarkably, the exogenous interleukin-12 totally blocked ultraviolet-B induced tumor necrosis factor alpha production ... Thus, interleukin-12 strongly inhibits tumor necrosis factor alpha production by noninflammatory skin cells, mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter
Shi et al., Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 1999 (Hepatitis, Viral, Human) : When PBMCs were cultured in the presence of IL-4 at a concentration of 100 U/ml, IL-4 down-regulated the production of both TNF-alpha and IL-1 alpha mRNA by acute phase PBMCs only to 18.18-21.98 % of control cells ( in absence of IL-4 ), while the inhibitory rates were all near to 50 % in recovery phases ... Moreover, it was also found that the suppressive effect of IL-4 on the expression of PBMCs TNF-alpha and IL-1 alpha mRNA in the patients with endotoxinemia and HBeAg was significantly decreased in acute phase ... The inhibitory effect of IL-4 on the expression of PBMCs TNF-alpha and IL-1 alpha mRNA is markedly decreased in acute phase as compared with that in recovery phase and this declined response may be related to endotoxinemia and viremia
Lin et al., Crit Care Med 2003 (Hyperoxia) : Endogenous nitric oxide may be an important endogenous inhibitor of hyperoxia + tumor necrosis factor-alpha induced leukocyte recruitment and subsequently tumor necrosis factor-alpha, interleukin-1 beta, and GRO/CINC-1 release
Cribbs et al., Int Immunol 2003 : QS21 and CFA induced significant IFN-gamma, IL-4 and tumor necrosis factor-alpha expression, whereas alum induced primarily IL-4 production
Xiao et al., J Dermatol Sci 2003 : Both IL-4 and IL-13 inhibit the TNF-alpha and IFN-gamma enhanced MDC production in a human keratinocyte cell line, HaCaT cells ... Both interleukin-4 (IL-4) and IL-13 inhibited TNF-alpha and IFN-gamma enhanced MDC production in HaCaT cells in a dose dependent manner
Gildea et al., Infect Immun 2003 (Histoplasmosis) : Analysis of total body and lung cytokine levels revealed that gamma interferon and tumor necrosis factor alpha production were not inhibited in the presence of excess IL-4
Mariano Andrade et al., Cell Immunol 2003 : GXM enhanced the secretion of IL-10 and IL-4 , while it reduced the production of pro-inflammatory cytokines TNF-alpha and IFN-gamma
Ghigo et al., Ann N Y Acad Sci 2003 : The effects of IL-4 on bacterial replication and on tumor necrosis factor (TNF) production in monocytes were apparently not related ... Although IL-4 inhibited C. burnetii stimulated release of TNF , the addition of recombinant TNF to IL-4 treated monocytes did not prevent the IL-4 effect
Jana et al., J Neurochem 2003 : Induction of tumor necrosis factor-alpha (TNF-alpha) by interleukin-12 p40 monomer and homodimer in microglia and macrophages
Maeda et al., J Invest Dermatol 2003 : Among T helper 1 cytokines, interleukin-4 mediated suppression of tumor necrosis factor-alpha was not affected by terfenadine, which, however, markedly restored mRNA expression of interferon-gamma or interleukin-2
Nomura et al., J Immunol 2003 (Dermatitis, Atopic...) : We found that IL-13 and IL-4 inhibited TNF-alpha- and IFN-gamma induced HBD-3 production
Mizrachi-Nebenzahl et al., Clin Exp Immunol 2003 (Disease Progression...) : Analysis of mRNA expression of cytokines in the spleen revealed no alterations in tumour necrosis factor (TNF)-alpha , transforming growth factor ( TGF ) -beta, interleukin (IL)-12 and interferon (IFN)-gamma and induction of IL-10 and IL-4
Sone et al., Nihon Kyobu Shikkan Gakkai Zasshi 1992 (Melanoma) : IL-4 inhibited the production of IL-1 and TNF-alpha by AM at the protein and mRNA levels
Ho et al., J Infect Dis 1992 : Interleukin-4 inhibits human macrophage activation by tumor necrosis factor , granulocyte-monocyte colony stimulating factor, and interleukin-3 for antileishmanial activity and oxidative burst capacity
Tucci et al., J Immunol 1992 (Thymoma) : IL-4 together with IL-1 induced IgE secretion, and the IgE secretion was further increased by TNF-alpha
Hart et al., Immunology 1992 : IL-4 reduced TNF-alpha production by monocytes when IL-4 and lipopolysaccharide (LPS) were added concomitantly, or upon subsequent activation by LPS 16 hr after first exposure to IL-4
Lorré et al., Eur Cytokine Netw 1992 : IL-4 , IL-6, GM-CSF and IFN-gamma had no effect on TNF-alpha production by T cells activated via either pathway
Limb et al., Immunology 1992 : The mean fluorescence intensity ( MFI ) of monocyte CD11a was enhanced by interleukin-2 (IL-2), TNF-alpha and TNF-beta, and that of CD11b, CD11c and CD18 was increased by IL-2, IL-4 , TNF-alpha and TNF-beta
Gauchat et al., Int Immunol 1992 : IL-5, IL-6, and TNF-alpha enhance IL-4 dependent IgE synthesis, but only TNF-alpha enhanced IL-4 induced germline epsilon RNA synthesis
Wagteveld et al., Leukemia 1992 (Leukemia, Myeloid, Acute) : In contrast, no secretion of growth factors was induced by IL-4, whereas in 2 cases IL-4 suppressed the IL-1 induced secretion of GM-CSF, TNF , and IL-6
Tada et al., Hokkaido Igaku Zasshi 1992 (Brain Neoplasms...) : TNF at a low dose ( 10 U/ml ) stimulated production of prostaglandin E2, Mn-superoxide dismutase, interleukin (IL)-6 and IL-8 by glioblastoma cells
Hazlett et al., Eye (Lond) 2003 (Corneal Ulcer...) : These data provide evidence that BALB/c mice can respond to exogenous IL-12, that the cytokine promotes susceptibility by increasing IFN-gamma and TNF-alpha production, with a concomitant reduction in IL-4 levels ; and that injected rIL-4 fails to rescue susceptible B6 mice from corneal perforation after bacterial challenge
Suzuki et al., J Exp Med 2003 : In this paper, we investigated the regulatory role of interleukin 4 (IL-4) in TNF-alpha production in mast cells ... IL-4 inhibited immunoglobulin E-induced TNF-alpha production and neutrophil recruitment in the peritoneal cavity in wild-type mice but not in signal transducers and activators of transcription 6 ( Stat6 ) -deficient mice ... IL-4 also inhibited TNF-alpha production in cultured mast cells by a Stat6 dependent mechanism ... Furthermore, IL-4 induced the expression of tristetraprolin (TTP), an RNA binding protein that promotes decay of ARE containing mRNA, in mast cells by a Stat6 dependent mechanism, and the depletion of TTP expression by RNA interference prevented IL-4 induced down-regulation of TNF-alpha production in mast cells
Ichiyama et al., Inflamm Res 2004 : Moreover, the inhibitory effects of IVIG on IkappaBalpha degradation, interleukin-6 (IL-6) production, and E-selectin expression induced by TNF-alpha were evaluated by Western blot analysis, ELISA, and flow cytometry, respectively
Koranteng et al., Clin Exp Immunol 2004 : At the protein level, SB203580 exerted little effect on TNF-alpha release but inhibited IL-4 release ; notably, the ratio of TNF-alpha : IL-4 increased markedly with the concentration of SB203580, confirming the differential regulation of these cytokines
Morgan et al., J Rheumatol 2004 (Arthritis, Experimental) : In vitro tumor necrosis factor-alpha (TNF-alpha) , interferon-gamma (IFN-gamma), and interleukin 6 (IL-6) responses were detected during reactions to most antigens tested, while IL-4 responses were absent
Cheon et al., J Rheumatol 2004 (Arthritis, Rheumatoid...) : When RA FLS are stimulated with interleukin 1 or tumor necrosis factor-a , WISP3 mRNA is significantly increased
Briolay et al., J Clin Immunol 1992 (Arthritis, Rheumatoid) : IL-4 inhibited the production of IL-6, IL-1 beta, and tumor necrosis factor alpha (TNF alpha) by both controls and rheumatoid patients
Jansen et al., Leukemia 1992 (Leukemia, Hairy Cell...) : Production of tumor necrosis factor-alpha by normal and malignant B lymphocytes in response to interferon-alpha, interferon-gamma and interleukin-4 ... Hairy cell leukemia ( HCL ) cells produced TNF alpha in the absence of stimuli and this production was markedly enhanced by addition of IFN alpha or, to a lesser extent, by IFN gamma and IL4
Sone et al., Eur Respir J 1992 : The effects of recombinant human interleukin-4 (IL-4) on the production of interleukin-1 (IL-1) and tumour necrosis factor-alpha (TNF alpha) by human alveolar macrophages ( AM ) and autologous peripheral blood monocytes ( PBM ) in response to lipopolysaccharide (LPS) were examined ... IL-4 also suppressed the production of IL-1 and TNF alpha by monocyte derived macrophages
Desmet et al., Biochem Pharmacol 2005 : On the contrary, both RSG and TRO significantly potentiated TNF-alpha induced production of granulocyte/macrophage-colony stimulating factor, interleukin (IL)-6 and/or IL-8 in these cells
He et al., Zhonghua Xue Ye Xue Za Zhi 2004 (Anemia, Aplastic) : In recovery SAA patients, the serum levels of TNF-alpha significantly decreased to ( 1.46 +/- 1.41 ) microg/L ( P < 0.01 ), and the levels of IL-4 increased markedly to ( 3.05 +/- 1.94 ) microg/L
Standiford et al., Pathobiology 1992 : Interleukin-4 differentially regulates tumor necrosis factor-alpha gene expression by human T lymphocytes and monocytes ... In this investigation we examine the regulatory effects of the lymphocyte product interleukin-4 (IL-4) on the gene expression of TNF-alpha from stimulated human peripheral blood monocytes ( PBM ) and T lymphocytes ... The suppressive effects of IL-4 appear to be dependent upon de novo protein synthesis, as cycloheximide abrogated the IL-4 induced reduction in TNF-alpha mRNA levels from PBM
Pechová et al., Folia Parasitol (Praha) 2004 : In cultures from C3H/HeN mice, SGE down regulated production of tumour necrosis factor alpha (TNF-alpha) and up regulated Th2 cytokine, interleukin 4 (IL-4)
Chen et al., Parasitol Int 2005 (Disease Models, Animal...) : On the other hand, neutrophil depletion of susceptible BALB/c mice did not affect the expression of TNF-alpha and monocyte derived chemokine (MDC) in peritoneal macrophages but induced the early stage expression of IL-4 in draining lymph node cells and exacerbated the footpad lesions and increased the parasite burden
Wang et al., Sichuan Da Xue Xue Bao Yi Xue Ban 2005 (Colitis, Ulcerative...) : The results indicated that thalidomide treatment significantly reduced colonic inflammation, suppressed NF-kappaB activation, enhanced TNF-alpha mRNA degradation, inhibited the synthesis of the TNF-alpha , IEN-gamma and increased the production of IL-4
Deveci et al., Mediators Inflamm 2005 (Tuberculosis, Pulmonary) : It has been reported that IFN-gamma, TNF-alpha , and IL-12 stimulate, and that IL-10, TGF-beta, and IL-4 suppress the protective immune response against tuberculosis
Hsu et al., Int Immunol 1992 : Both IL-4 and IL-10 [ cytokine synthesis inhibitory factor ( CSIF ) ] inhibit IL-2 induced synthesis of IFN-gamma and tumor necrosis factor (TNF)-alpha by human PBMC
De Francesco et al., Virus Res 2006 : The results show that p17, while ineffective on resting monocytes, exerts an inflammatory action on IL-4 mediated inhibition of TNF-alpha and IFN-gamma production induced by IL-15 stimulation
Totpal et al., Cancer Res 1991 (Breast Neoplasms...) : IL-4 had no effect on the growth-stimulatory activity of TNF on normal human foreskin fibroblasts
Leonardi et al., Clin Exp Allergy 2006 (Conjunctivitis, Allergic) : In addition IL-4 , IFN-gamma, and IL-10 were elevated in SAC and VKC, while eotaxin and TNF-alpha were only increased in VKC
Thornhill et al., J Immunol 1990 : IL-4 regulates endothelial cell activation by IL-1, tumor necrosis factor , or IFN-gamma
Kasid et al., Cancer Res 1990 : Interestingly, IL-4 in combination with IL-2 inhibited the IL-2-driven induction of TNF and LT mRNA
Van Damme et al., J Invest Dermatol 1990 : This study focuses on interferon-beta (IFN-beta), interleukin-6 (IL-6), and interleukin-8 (IL-8) production by fibroblasts and epithelial cells in response to interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha)
Yang et al., Zhonghua Jie He He Hu Xi Za Zhi 2006 (Tuberculosis, Pulmonary) : IL-7 and IL-15 could affect the balance between Th1 and Th2 cytokines by inducing IFN-gamma and TNF-alpha production and inhibiting IL-4 and IL-10 expression
Guillermo et al., J Leukoc Biol 2007 (Chagas Disease) : Anti-FasL, but not anti-TNF-alpha or anti-TRAIL, blocked activation induced cell death of CD8 T cells and increased secretion of IL-10 and IL-4 by CD4 T cells from T. cruzi infected mice
Albanesi et al., J Immunol 2007 : IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3
Matsuda et al., Am J Respir Cell Mol Biol 2008 : These results suggest that, in the presence of TNF-alpha , IL-4 and IFN-gamma reciprocally regulate tube formation by HMVEC-Ls through autocrine synthesis of CXCR2 and CXCR3 chemokines, respectively
Choi et al., FEMS Immunol Med Microbiol 2007 (Candidiasis) : CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving tumor necrosis factor-alpha dependent interleukin-12 induction
Shembade et al., J Virol 2007 : Mouse fibroblasts lacking Ubc13 exhibit impaired Tax activation of NF-kappaB despite normal tumor necrosis factor- and interleukin-1 mediated NF-kappaB activation
Noguchi et al., Int Immunol 2007 (Colitis) : The blockade of IL-6 signaling enhanced the generation of IL-4- and IL-10 producing CD4 ( + ) T cells, and inhibited up-regulation of tumor necrosis factor -alpha mRNA expression in the colon
Yamada et al., J Ethnopharmacol 2008 (Leukemia, Basophilic, Acute) : Different dilutions of Sayali olive oil dose-dependently inhibited the production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-4 (IL-4), and different dilutions of Zarrazi olive oil dose-dependently inhibited histamine release and IL-4 production by calcium ionophore A23187 plus phorbol 12-myristate 13-acetate ( PMA ) -stimulated KU812 cells
Rachakonda et al., Arthritis Rheum 2008 (Disease Models, Animal...) : Using articular chondrocytes, we showed that our COX-2 promoter construct expressed IL-4 only in the presence of IL-1beta and TNFalpha ... IL-4 expressed in the presence of IL-1beta and TNFalpha down-regulated a series of inflammation mediators, prostaglandins, and matrix metalloproteinases
Inagaki et al., J Biol Chem 2008 : Tumor necrosis factor- and interleukin-1 induced activation of TAK1 was entirely normal in Tab1-deficient MEFs and could activate both mitogen activated protein kinases and NF-kappaB
Bello-Fernandez et al., Immunology 1991 (Neoplasms) : TNF levels induced by IL-2 were similarly reduced by IL-4 both in normal donors ( P less than 0.003 ) and in patients ( P less than 0.01 )
Stenger et al., Eur J Immunol 1991 (Leishmaniasis) : First, both IFN-gamma and IL 4 as single agents and in combination were potent inducers of TNF-alpha production by M phi infected with L. major amastigotes
Schmidt et al., Eur J Immunol 2009 : Furthermore, the production of IL-4 was severely impaired, and GM-CSF, TNF-alpha and IL-13 levels were also diminished
Fischer et al., J Immunol 1990 : IL-2 and IL-4 were both growth promoting for human T cells but only IL-2 could efficiently induce TNF production
Hart et al., Immunology 1991 : To investigate whether opposing activities of IL-4 reflect a difference in the target cell studied, due either to cell maturation or the site from which the cells were isolated, we examined the effect of IL-4 on human peritoneal macrophage production of IL-1 beta, TNF-alpha and prostaglandin E2 ( PGE2 )
Woodward et al., Immunology 2010 : We investigated whether the early induction of SOCS1 by IL-4 was responsible for the suppression of LPS induced tumour necrosis factor (TNF)-alpha production by IL-4 ... IL-4 suppressed LPS induced TNF-alpha in freshly isolated monocytes at the level of transcription but acted by a different, possibly translational, mechanism in monocytes cultured overnight in macrophage colony stimulating factor ( M-CSF )
Tyagi et al., Mol Cell Endocrinol 2010 : In addition, like 17beta-estradiol, presence of medicarpin inhibited TNFalpha induced upregulation of interleukin-1 , and -6 mRNA levels in osteoblasts
Gutteberg et al., APMIS 1991 (Sepsis) : Using a whole blood in vitro model, we have investigated the effect of Escherichia coli ( E. coli ), Streptococcus agalactiae ( group B streptococci, GBS ) and tumor necrosis factor alpha (TNF) on the generation of lactoferrin (LF), interleukin-1 beta (IL-1) and tissue thromboplastin (TPL) in healthy newborns at term and their mothers
Zhang et al., Cell Physiol Biochem 2010 : TNF increases expression of IL-4 and PARs in mast cells ... The results showed that TNF induced up to 2.7-fold increase in IL-4 , but not IL-12 release from P815 cells, and PAR-2 antagonist peptide FSLLRY-NH ( 2 ) and PAR-4 antagonist peptide trans-cinnamoyl ( tc ) -YPGKF-NH ( 2 ) did not affect TNF induced IL-4 release ... In conclusion, TNF can stimulate IL-4 release from mast cells through an Akt cell signalling pathway dependent, but PAR independent mechanism
Leonardi et al., Clin Exp Allergy 2011 (Conjunctivitis, Allergic) : In conjunctival fibroblast cultures, Smad-3 and PIP were stimulated by histamine, IL-4 , -13 and TGF-ß1 exposure, while PIP was reduced by IFN-?, and TNF-a mRNA expression of Smad-3 was increased by histamine, while Smad-7 was reduced by IL-4
Hart et al., Lymphokine Res 1990 : IL-4 can also suppress the increased release of IL-1 beta and TNF alpha by monocytes incubated with indomethacin, a non-steroidal anti-inflammatory drug
Elias et al., Chest 1990 (Pneumonia...) : To understand the processes regulating inflammation and fibrosis in the human lung, we characterized the effects of recombinant interleukin-1, tumor necrosis factor , and gamma interferon on fibroblast proliferation, collagen production, interleukin-1-alpha production, interleukin-1-beta production, and interleukin-6 production
te Velde et al., Blood 1990 : To elucidate which cytokines produced by monocytes are controlled by IL-4, we tested the effect of IL-4 on the secretion of IL-1 alpha, IL-1 beta, TNF alpha, and IL-6 induced by LPS or IFN gamma ... IL-4 was found to inhibit the secretion of IL-1 beta and TNF alpha by activated monocytes almost 100 % ... The reduced secretion of IL-1 beta and TNF alpha was specifically induced by IL-4 because anti-IL-4 antiserum completely restored normal monokine production
Boom et al., Infect Immun 1990 (Leishmaniasis) : This suggests that tumor necrosis factor , in addition to gamma interferon, may be involved in resistance to L. major and that interleukin-4 may inhibit the leishmanicidal activity of tumor necrosis factor and/or gamma interferon
Macedo et al., Inflammation 2012 (Cystitis...) : Exogenous IL-4 also attenuated TNF-a , IL-1ß, iNOS, and COX-2 expressions in ifosfamide treated bladders
Chan et al., Int J Oncol 1997 : Involvement of interleukin-1 in the differentiation inducing activity of tumor necrosis factor-alpha on a murine myeloid leukemia ( WEHI-3B JCS )
Carlo et al., J Pediatr 2011 (Cerebral Palsy...) : The analyses were focused on 5 cytokines ( interleukin [ IL] 1ß ; IL-8 ; tumor necrosis factor-a ; regulated upon activation, normal T-cell expressed, and secreted ( RANTES ) ; and IL-2 ) reported to be most predictive of CP in term and late preterm infants
Gehrmann et al., PloS one 2011 (Dermatitis, Atopic) : These vesicles can induce IL-4 and TNF-a responses with a significantly higher IL-4 production in patients compared to HC
Takeda et al., Int Immunopharmacol 2011 (Orthomyxoviridae Infections) : On day 2, tumor necrosis factor (TNF)-a production in BALF was also reduced significantly, but interferon-a, interleukin-12 , and interferon-? productions were augmented and natural killer ( NK ) cell activity was significantly elevated
Luzina et al., Cytokine 2012 (Asthma) : Stimulation of cultured T lymphocytes with IL-4d2 caused elevated production of IFN-?, IL-10, IL-6, MCP-1, and TNF-a , with notable differences between patients and controls in the production of IFN-?, IL-10, and IL-6
Ma et al., J Pharmacol Sci 2012 : We also demonstrated that pretreatment of cells with this compound prevented TNF-a induced expression of NF-?B target genes, such as interleukin 6, interleukin 8, monocyte chemotactic protein 1, cyclooxygenase-2 and inducible nitric oxide
Villacres et al., J Infect Dis 2012 (HIV Infections...) : Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure interleukin 1ß (IL-1ß), interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 12 (IL-12), and tumor necrosis factor a (TNF-a) responses to Toll-like receptor (TLR) 3 and TLR4 stimulation
Choi et al., Allergy 2012 (Asthma...) : In terms of T-cell response, the production of IL-4 from lung T cells after OVA challenge was enhanced by airway sensitization with OVA plus low-dose poly [ I:C ] in WT mice, and this phenotype was inhibited by the absence of TNF-a
Gunaydın et al., J Pediatr Surg 2012 (Acute Lung Injury...) : Aspiration of gastrointestinal decontamination agents produced histopathologic changes, elevated levels of malondialdehyde and surfactant protein D, reduced levels of antioxidant enzymes, and increased expression of inflammatory cytokines interleukin-1ß and tumor necrosis factor a. Curcumin treatments effectively attenuated the rats ' pulmonary inflammation responses ( as shown by reduced alveolar damage ), decreased serum malondialdehyde and surfactant protein D levels, and inhibited the expressions of tumor necrosis factor a and interleukin-1ß
McBride et al., Cancer Res 1990 : In contrast to IL-2, recombinant murine interleukin 4 (IL-4) down-regulated TNF synthesis by macrophages ... Overall, these results demonstrate that IL-2 and IL-4 can act antagonistically to regulate TNF production by macrophages
Souza et al., Br J Pharmacol 2013 : IL-4 and IL-13 inhibit IL-1ß and TNF-a induced kinin B1 and B2 receptors through a STAT6 dependent mechanism
Sharmin et al., Microbiol Immunol 2013 : Moreover, pyriproxyfen induced higher titers of IgG2a and enhanced tumor necrosis factor-alpha and gamma-interferon responses whereas alum induced IgG1 with enhanced interleukin-4 and -10
Elias et al., Am J Respir Cell Mol Biol 1990 : We determined whether normal human lung fibroblasts expressed cell associated thymocyte stimulating activity in response to recombinant interleukin-1 ( rIL-1 ) ( alpha and beta ) and recombinant tumor necrosis factor ( rTNF )
Tsukamoto et al., Inflamm Bowel Dis 2013 : : Enzyme linked immunosorbent assay and AP assay showed interleukin-1ß induced TNF-a shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells
Gowen et al., Endocrinology 1990 : Human osteoblast cultures derived as out-growths from trabecular bone released tumor necrosis factor ( TNF alpha ) upon stimulation of the cells with human recombinant interleukin 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ), human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ), and bacterial lipopolysaccharide ( 5-500 ng/ml )
Liu et al., J Immunol 1990 : Although perforin ( hemolytic ) activity was detected in unstimulated R8i, it was induced 2- to 14-fold in the presence of IL-2, IL-3, IL-4 , and IL-6, and to a lesser degree ( less than 4-fold ) by TNF and IFN-gamma
Peschel et al., Blood 1989 : Northern analysis of RNA from IL-4 induced and uninduced stromal cells indicated that IL-4 did not upregulate expression of CSF-1 or transforming growth factor-beta ( TGF-beta ) and only modestly increased expression of tumor necrosis factor , suggesting that these cytokines were not responsible for the inhibitory activity
Essner et al., J Immunol 1989 : The effects of IL-4 on IL-1 and TNF gene expression in human peripheral monocytes ( PBM ) were examined ... RNA hybridization studies demonstrated that IL-4 does not induce transcription of IL-1 or TNF
Palladino et al., Ciba Found Symp 1987 (Neoplasms, Experimental) : Apart from their direct cytotoxic/cytostatic activities against tumours in vitro and in vivo, the in vivo antitumour activities of TNF-alpha or TNF-beta may involve the following biological activities : the induction of interleukin 1 production ; activation of polymorphonuclear neutrophil functions ; modulation of endothelial cell functions ; and augmentation of specific immune functions
Bachwich et al., Biochem Biophys Res Commun 1986 : Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages ... We have investigated the effect of tumor necrosis factor on the release of interleukin-1 and PGE2 from murine resident peritoneal macrophages ... Tumor necrosis factor causes an increase in the production of interleukin-1 and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M
Hoffman et al., Lymphokine Res 1986 : The effects of tumor necrosis factor on the production of interleukin-1 by macrophages
Le et al., J Immunol 1987 : Induction of membrane associated interleukin 1 by tumor necrosis factor in human fibroblasts
Männel et al., Rev Infect Dis 1987 : No TNF induced production of interleukin 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures
Libby et al., Am J Pathol 1986 : Endotoxin and tumor necrosis factor induce interleukin-1 gene expression in adult human vascular endothelial cells
Ferreira et al., Drugs 1993 (Hyperalgesia...) : The release of tumour necrosis factor-alpha (TNF-alpha) initiates the release of interleukin-1 and interleukin-8, which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines, respectively
Cavaillon et al., Pathol Biol (Paris) 1993 (Inflammation) : TGF beta, IL-4 , and IL-10 inhibit production of IL-1 and TNF
Hart et al., J Leukoc Biol 1995 : Seven-day cultured monocytes/macrophages showed ( 1 ) diminished TNF-alpha production in response to IL-10 but not IL-4 ( 2 ), diminished IL-1 beta production in response to both IL-4 and IL-10, and compared with fresh monocytes ( 3 ), diminished CD14 expression in response to IL-4, and ( 4 ) a lesser increase in CD23 expression in response to IL-4
Benveniste et al., Int J Dev Neurosci 1995 : In this study, we demonstrate that transforming growth factor-beta ( TGF-beta ), interleukin-10 (IL-10) and interleukin-6 (IL-6) inhibit tumor necrosis factor-alpha expression by primary rat astrocytes
Tsuji et al., Am J Pathol 1995 (Granuloma...) : Thus, interleukin-1 alpha and inducible nitric oxide synthase were induced mostly in the cells accumulated around the beads and also in some bronchiolar epithelial cells during the early phase ( 1 to 3 days ), whereas tumor necrosis factor-alpha was induced in the cells around the beads at the later resolution phase ( 3 to 7 days )
Sperber et al., Clin Diagn Lab Immunol 1995 : In LPL, there was no SEE induced IL-2 or IL-4 production, but IL-6, TNF , and gamma interferon were induced ... In IEL, SEE induced no IL-2, IL-4 , or gamma interferon but produced IL-6 and TNF, while SEB stimulation resulted in no IL-2 or gamma interferon but did result in detectable IL-4, IL-6, and TNF
Armant et al., J Immunol 1995 : The sCD23 induced TNF-alpha production is significantly inhibited by IL-4 and IL-10 but not by TGF-beta
Sandborg et al., J Immunol 1995 : IL-12 had an inhibitory effect on PBMC IL-4 production as previously described, but neither IL-6 nor TNF-alpha inhibited IL-4 production
Taylor-Fishwick et al., Transplantation 1993 : Unexpectedly, rapamycin actually synergized with IL-4 in both the upregulation of CD23 expression and the down-regulation of the type II ( p75 ) TNF receptor, while in the same B cell line, rapamycin simultaneously inhibited the IL-4 dependent production of TNF alpha and beta
Hart et al., J Immunol 1993 (Arthritis...) : In contrast to the response by blood monocytes, the response to IL-4 by synovial fluid cells was selective ; IL-4 did not significantly suppress LPS induced TNF-alpha production, but decreased CD14 expression to a similar extent in the two cell populations
Aggarwal et al., Exp Cell Res 1995 : Diminished responsiveness of senescent normal human fibroblasts to TNF dependent proliferation and interleukin production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B
Liew et al., Immunol Lett 1994 (Autoimmune Diseases...) : The regulatory mechanisms so far known to control NO synthesis include cytokines ( induction of NO synthase by IFN-gamma, TNF alpha, MIF and LPS, and down regulation by IL-4 , IL-10 and TGF beta ), feedback inhibition by NO itself, inhibition by pretreatment with LPS and glycoinositol-phospholipids and up regulation by lipophosphoglycan from the protozoa parasite, Leishmania major
Hart et al., Immunology 1995 (Arthritis) : Because IL-10 and IL-4 differentially regulate TNF-alpha and IL-1ra production by synovial fluid mononuclear cells, selective use of either IL-10 or IL-4 in the treatment of chronic inflammatory conditions will depend on whether TNF-alpha or IL-1, respectively, is established as primarily responsible for the maintenance of the chronic inflammatory condition
Chanez et al., J Allergy Clin Immunol 1994 (Asthma) : The effects of IL-4 on the release of IL-1, tumor necrosis factor-alpha , and IL-6 by monocytes and alveolar macrophages were compared in 19 patients with asthma and 18 control subjects
Judd et al., Am J Physiol 1995 : ZG cells released IL-6 and TNF , and this release was stimulated by lipopolysaccharide, interleukin-1 alpha, interleukin-1 beta, a protein kinase C activator, and a calcium ionophore without affecting intracellular adenosine 3 ', 5'-cyclic monophosphate ( cAMP ) content
Yano et al., J Leukoc Biol 1995 : IL-4 , IL-10, and IL-13 suppressed the generation of antitumor activity and cytokine production ( IL-1 beta and TNF-alpha ) of monocytes stimulated with MCAF plus norMDP or LPS
Rhoades et al., Cell Immunol 1995 : Regulation of TNF-alpha promoter activity by IL-2, IFN-gamma, GM-CSF, and IL-4 was examined in the U937 macrophage cell line and the MLA 144 T cell line
Zhou et al., J Leukoc Biol 1994 (Inflammation) : Interleukin-4 , when added together with bacterial lipopolysaccharide (LPS), suppressed LPS induced increases in mRNA levels of IL-1 alpha, IL-1 beta, IL-8, and TNF-alpha in alveolar macrophages
Joyce et al., Eur J Immunol 1994 : We, therefore, investigated the effects of IL-10 and IL-4 on the cell surface expression and release of TNF-R by human monocytes to determine whether these cytokines also indirectly modulated the biological activity of TNF-alpha
Seatter et al., Arch Surg 1994 (Disease Models, Animal) : Tumor necrosis factor and interleukin-1 regulation by lipopolysaccharide pretreatment
Rosenstein et al., J Rheumatol 1994 : Piroxicam treatment resulted in elevation of levels of IL-2, depression of IL-1, IL-6, TNF alpha and IFN-gamma, and no consistent effect on IL-4
Naume et al., Cytokine 1993 : Furthermore, IL-4 induced a slight increase in the IL-12 stimulated TNF production
Blasi et al., Infect Immun 1994 : Moreover, pretreatment of macrophages with recombinant TNF for 3 h enhances TNF and induces interleukin-1 production in response to both forms of Candida, while pretreatment for 18 h renders macrophages refractory to any stimuli
Miossec et al., Rev Rhum Ed Fr 1993 (Arthritis, Rheumatoid...) : Since IL4 inhibits the production of proinflammatory cytokines such as IL1, IL6, TNF alpha and IL8, we hypothesized that a deficit in IL4 production might be related to the pathogenesis of rheumatoid arthritis
Puri et al., Biochem Biophys Res Commun 1993 (Sarcoma, Experimental) : Tumor necrosis factor upregulates interleukin-4 receptors on murine sarcoma cells ... In the present study, we have examined the regulation of IL-4R by TNF
Reittie et al., Leuk Res 1994 (Leukemia, Lymphocytic, Chronic, B-Cell) : We studied the effects of IL-4 on tumour necrosis factor (TNF) induced and spontaneous proliferation ( 3H-TdR incorporation ) and spontaneous release of TNF and interleukin-6 (IL-6) by purified B-cell chronic lymphocytic leukaemia ( CLL ) cells in vitro ... When added at the start of 5 day cultures, IL-4 inhibited both spontaneous ( 41 +/- 17 % inhibition, n = 3 ) and TNF induced ( 46 +/- 5 % inhibition, n = 9, p = 0.01 ) 3H-TdR uptake ... IL-4 ( whether added at T0 or T48h ) also inhibited spontaneous release of TNF and IL-6 measured at 48 and 120 h. TNF and IL-4 had no consistent effect on normal cord blood CD5+ B-cells ... These data show that IL-4 has inhibitory effects on B-CLL DNA synthesis and also inhibits spontaneous release of IL-6 and TNF in vitro
Suk et al., Immunology 1993 (Neoplasms, Experimental) : IFN-gamma and IL-4 increased lipopolysaccharide (LPS) induced TNF-alpha production by different mechanisms because IL-4, unlike IFN-gamma, failed to overcome the LPS-hyporesponsiveness in C3H/HeJ mice
Bogdan et al., Ann N Y Acad Sci 1993 : Thus, TGF-beta, but not IL-4 or IL-10, can induce resting human monocytes to produce TNF , IL-1, and IL-6
Larsson et al., Leukemia 1993 (Leukemia, Lymphocytic, Chronic, B-Cell) : IL-4 did not have any major effects on the production of TNF-alpha in activated cells, but inhibited the IL-2 induced production of TNF-alpha in SAC activated cells
Lee et al., Leuk Res 1993 : Interleukin-4 (IL-4) down-regulated TNF-alpha production by monocytes, but in contrast interferon-gamma (IFN-gamma) moderately enhanced TNF-alpha production
Bendrups et al., Rheumatol Int 1993 (Arthritis, Rheumatoid...) : The effects of recombinant human interleukin-4 (IL-4) and the glucocorticoid, dexamethasone, on tumor necrosis factor alpha (TNF alpha) and interleukin-1 beta (IL-1 beta) levels in cultures of rheumatoid and osteoarthritic synovial tissue were studied
Sieling et al., J Immunol 1993 (Leprosy...) : Our study indicated that endogenous IL-4 production inhibited IL-10 secretion and, concomitantly, increased TNF-alpha and GM-CSF release
Kambayashi et al., Cell Immunol 1996 : The inhibitory effect of IL-4 and IL-13 on the release of TNF alpha was partially reversed by neutralizing anti-IL10 antibody, and the inhibition of IL-6 release was completely reversed by the antibody
Suk et al., Immunology 1996 : IFN-gamma and IL-4 increased lipopolysaccharide (LPS) induced TNF-alpha , IL-1 steady-state message levels ... Thus IFN-gamma and IL-4 may differentially affect the post-transcriptional control of TNF-alpha gene expression
Joyce et al., Cytokine 1996 : LPS stimulated release of TNF-alpha declined substantially after the first day and was consistently suppressed by IL-10 and IL-4 but increased by IFN-gamma
Becher et al., J Clin Invest 1996 : Soluble tumor necrosis factor receptor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro
Sawyer et al., Eur Surg Res 1996 (Acute Disease...) : Interleukin-4 prevents mortality from acute but not chronic murine peritonitis and induces an accelerated tumor necrosis factor-alpha response
Joyce et al., J Interferon Cytokine Res 1996 : IL-4 , IL-10, TGF-beta, and glucocorticoids ( GC ) all suppress the lipopolysaccharide (LPS) stimulated release of TNF-alpha and IL-1beta but vary in their effects on IL-1RA and sTNF-R
Hart et al., J Immunol 1996 (Arthritis, Rheumatoid) : Regulation of surface and soluble TNF receptor expression on human monocytes and synovial fluid macrophages by IL-4 and IL-10 ... The predominant TNF receptor on monocytes, the p75 receptor, was down-regulated by IL-4 at the mRNA level ... Addition of an Ab to IL-10 suggested that the stimulatory effects of LPS on p75 TNF receptor expression were due, at least in part, to LPS stimulation of IL-10 production and that IL-4 acted , in part, by decreasing IL-10 production
Poulsen et al., Cytokine 1996 (Dermatitis, Atopic...) : The AD group demonstrated a significantly lower production of TNF-alpha and IFN-gamma compared with the two other groups, and IL-4 and IL-5 production increased in the IA group
Yamamoto et al., Eur J Pharmacol 1996 (Disseminated Intravascular Coagulation) : Plasma interleukin-1 and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) inhibited the increased plasma interleukin-1 ( 100.0 % ) and plasma TNF-alpha ( 89.2 % ) levels
Ortiz-Arduan et al., Am J Physiol 1996 (Endotoxemia) : Lipopolysaccharides (LPS), interleukin-1 beta, interferon-gamma (IFN-gamma), and TNF-alpha increase the levels of Fas mRNA in cultured mesangial and tubular cells
Hu et al., Blood 1997 : TNF-alpha and IL-6 enhanced IFN-gamma production, but suppressed IL-4 production in the cultures
Lugli et al., J Biol Chem 1997 : Nevertheless, TNF-alpha stimulation led to increased activation of the IL-4-specific signal transducers and activators of transcription protein ( Stat6 ) by IL-4 and IL-13
Klegeris et al., Brain Res 1997 (Alzheimer Disease) : First, it was shown that THP-1 cells could be induced to secrete significant amounts of TNF-alpha by interleukin-1 , lipopolysaccharide, interferon-gamma (IFN-gamma) and PMA alone or in combination with each other
Ferreri et al., Cytokine 1997 : These results demonstrate that PGE2 does not affect LT-beta, IL-4 , or IL-3 in Th2 cells, but inhibits TNF mRNA accumulation and production in this T cell subset
Mijatovic et al., J Biol Chem 1997 : The production of tumor necrosis factor-alpha (TNF-alpha) by lipopolysaccharide (LPS) stimulated macrophages can be markedly inhibited by the two closely related cytokines, interleukin (IL)-4 and IL-13
Berghella et al., Cancer Immunol Immunother 1998 (Colorectal Neoplasms) : To address these questions at the immunological level in a group of patients and healthy subjects, we determined the sIL-2R level in the serum and its release from peripheral blood mononuclear cells ( PBMC ) as a function of tumour necrosis factor (TNF) alpha , IL-1 alpha, IL-1 beta, IL-2, interferon (IFN) gamma, IL-4, IL-6 and IL-10 levels in the serum and PBMC production ; and PBMC proliferative responses to IL-2, IL-4 and anti-CD3 monoclonal antibody ( CD3 ), variously combined
Li et al., Eur J Pharmacol 1998 (Multiple Sclerosis) : Production of tumor necrosis factor-alpha and the lysosomal cysteine proteinase cathepsin B were markedly inhibited, but production of interleukin-1 increased
Bonder et al., J Immunol 1998 : Studies with Abs to gammac and an IL-4 mutant that is unable to bind to gammac showed that IL-4 can suppress IL-1beta but not TNF-alpha production by LPS stimulated monocytes in the presence of little or no functioning gammac ... IL-4 also suppressed IL-1beta but not TNF-alpha production by Mono Mac 6 cells, which express minimal levels of gammac
Bryson et al., Arch Biochem Biophys 1998 : It potently inhibited interleukin 1- and tumor necrosis factor stimulated proteoglycan release from both nasal and articular cartilage
Fiedler et al., Am J Respir Cell Mol Biol 1998 : The working hypothesis of the studies described herein was that inhibition of proteasome mediated IkappaB degradation would inhibit TNF-alpha induced nuclear factor-kappaB (NF-kappaB) activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells
Aihara et al., Dig Dis Sci 1998 : Live H. pylori induced production of many cytokines, such as IL-1beta, IL-10, IL-8, IFN-gamma, and TNF-alpha , whereas we could not detect IL-2 or IL-4
Schluep et al., Mult Scler 1998 (Disease Progression...) : When cytokine levels were analysed independently from MS clinical activity, the use of AZA inhibited IgG OB and TNF-alpha synthesis ( P = 0.002 ) but increased IL-4 ( P = 0.0024 ), whereas IFN-beta 1a stimulated TNF-alpha and inhibited IgG OB and IL-4 production
Fulton et al., J Infect Dis 1998 : Regulation of interleukin-12 by interleukin-10, transforming growth factor-beta, tumor necrosis factor-alpha , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra
Manna et al., J Biol Chem 1998 : How IL-4 regulates various activities of TNF is not fully understood ... In the present report, we investigated the effect of IL-4 on the cell surface TNF receptors in human histiocytic lymphoma U-937 cells ... IL-4 's effect on TNF receptors was not cell type-specific, since decreases also occurred on various epithelial and T cells ... Wortmannin reversed the IL-4 induced TNF receptor down-regulation and all other measured cellular responses, indicating a critical role of phosphatidylinositol 3-kinase
Chan et al., Biochem Biophys Res Commun 1998 : Because various members of the mitogen activated protein kinases and their upstream kinases have been shown to directly or indirectly activate a number of transcription factors including AP-1 and NFkappaB, we examined the effects of IL-4 on TNF-alpha activation of the MAPKs
Wei et al., J Surg Res 1999 : We investigated the role of anti-TNF in the regulation of MHC class II antigens and cytokine mRNA expression of TNF, interferon-gamma (IFN), IL-2, IL-4 , and IL-10 in cardiac allografts to elucidate its immunological mechanism