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CD4 — TNF

Text-mined interactions from Literome

El-Sheikh et al., J Autoimmun 1999 (Diabetes Mellitus, Type 1) : Depletion of either CD4 ( + ) or CD8 ( + ) T cells may prevent beta-cell destruction by decreasing IFN-gamma and IL-10 production in islets and increasing IL-4 and TNF-alpha production systemically
Martin et al., Infect Immun 2001 : In a coculture system, CT-treated CD4 ( + ) T cells induced significantly less TNF-alpha and IL-12 p70 production by both autologous monocytes and monocyte derived dendritic cells than either LT-IIa- or LT-IIb treated CD4 ( + ) T cells
Tsukadaira et al., Int Arch Allergy Immunol 2001 : Theophylline inhibits TNF-alpha induced CD4 expression on human eosinophils and CD4+ eosinophil migration
Romas et al., Bone 2002 (Arthritis, Rheumatoid) : Production of tumor necrosis factor-alpha (TNF-alpha) and other proinflammatory cytokines in RA is largely CD4 ( + ) T-cell dependent and mostly a result of interferon-gamma (IFN-gamma) secretion
Brown et al., J Immunol 2002 (Graft vs Host Disease...) : The present studies were designed to evaluate whether TNF-TNFR2 interactions were involved in the in vivo generation of CD4 ( + ) T cell mediated intestinal graft-versus-host disease ( GVHD ) in the ( C57BL/6J ( hereafter called B6 ) -- > B6 x B6.C-H-2 ( bm12 ) ( bm12 ) ) F ( 1 ) GVHD model
Banda et al., J Immunol 2003 (Arthritis, Experimental) : The production of IFN-gamma, TNF-alpha , and IL-1beta in cultured spleen cells was reduced by in vivo treatment with low dose, but not high dose, mIL-18BP. FACS analysis showed a slight decrease in NK cells and an increase in CD4 ( + ) T cells in spleens of mice treated with mIL-18BP
Brown et al., J Immunol 2003 (Colonic Diseases...) : These findings indicate that TNF promotes CD4 ( + ) T cell alloproliferation, IFN-gamma responses, and intestinal GVHD by IL-12 independent mechanisms
Hata et al., J Clin Invest 2004 (Arthritis, Experimental...) : Thus, IL-6, IL-1, TNF-alpha , and IL-10 play distinct roles in the development of SKG arthritis ; arthritogenic CD4 ( + ) T cells are not required to skew to either Th1 or Th2 ; and the appearance of rheumatoid factor is independent of joint inflammation
Ferland et al., J Immunol 2004 : TNF-pretreatment increased surface membrane CD4 ( + ) expression by 6-fold as previously described, and increased IL-16 induced cell migration by 2.2-fold
Merrill et al., J Virol 1992 : Soluble recombinant CD4 did not block TNF alpha and IL-1 production
Cassatella et al., Immunology 1992 : In this study we investigated the effects of TNF and IFN-gamma on the expression of the CD4 protein and messenger RNA ( mRNA ) in the two myeloid cell lines, ML3 and HL-60 ... We observed that CD4 antigen expression on ML3 cells is almost undetectable and that TNF and IFN-gamma induced CD4 antigen expression on these cells
Singh et al., J Virol 2007 (Acute Disease...) : Indirect regulation of CD4 T-cell responses by tumor necrosis factor receptors in an acute viral infection
Yamada et al., Clin Immunol 2007 (Arthritis, Rheumatoid) : Furthermore IL-15 stimulated CD57 ( + ) CD28 ( - ) CD4 ( + ) T cells induced TNF-alpha production from monocytes
Cambos et al., Int J Parasitol 2008 (Anemia...) : Interestingly, a potent induction of TNF-alpha and IFN-gamma production by CD4+ and CD90 ( - ) lymphocytes was measured in DS-infected mice, which also suffered severe anaemia earlier than non depleted infected controls
Noguchi et al., Int Immunol 2007 (Colitis) : The blockade of IL-6 signaling enhanced the generation of IL-4- and IL-10 producing CD4 ( + ) T cells, and inhibited up-regulation of tumor necrosis factor -alpha mRNA expression in the colon
Cornejo-Garcia et al., Allergy 2007 (Drug Hypersensitivity...) : In DR, IFN-gamma, TNF-alpha and T-bet increased significantly in both CD4 and CD8 subpopulations, depending on the clinical severity
Nishikawa et al., Cancer Res 2008 : We previously found that a Salmonella typhimurium vector engineered to secrete soluble tumor antigen induces CD4 ( + ) T cells resistant to CD4 ( + ) CD25 ( + ) regulatory T cells ( Treg ) and that glucocorticoid induced tumor necrosis factor receptor family related gene ( GITR ) signal is involved in the development of this resistance
Hassan et al., Leuk Res 1991 (Leukemia, Hairy Cell) : TNF induced expression of CD4 and CD71, increased the intensity of HLA-DR, CD25, CD11c and CD13 expression and decreased both the intensity and frequency of sIg and cIg positivity ... alpha-IFN decreased CD25 expression, the tartrate-resistant acid phosphatase activity ( TRAP ), reduced the TNF induced CD4 and CD71 expression and antagonized the TNF effect on the Ig expression
Du et al., Chin J Integr Med 2009 (Carcinoma, Non-Small-Cell Lung...) : The level of CD3 ( + ), CD4 ( + ), the ratio of CD4 and CD8 ( + ), IgA, IgM, IgG and IL-2 decreased in patients with NSCLC on day 1 after operation, and the level of CD8 and TNF-alpha increased compared to pre-operation
Zhou et al., Zhonghua Yi Xue Za Zhi 2009 (Inflammation...) : The level of TNFalpha decreased, and the numbers of CD ( 3 ) ( + ) and CD(4) ( + ) T lymphocytes increased significantly on day 4 in Combined Therapy Group ( P < 0.05 or P < 0.01 )
Robinet et al., J Immunol 1990 : TNF did not affect the expression of LFA1, CD2, CD4 , and CD8, molecules that are associated with CTL-target interactions, on responder cells
Ryba et al., Cytokine 2011 (Diabetes Mellitus, Type 1...) : It indicates that TNF reduces the number and frequency of regulatory CD4 ( + ) Foxp3 ( + ) T cells in children with diabetes type 1 and that in vitro treatment with anti-TNF antibody seems to rescue this cell subset from its defective effects
Kothari et al., Indian journal of clinical biochemistry : IJCB 2006 : Despite the rising IL-10 mRNA levels, TNF-a mRNA levels increased with severity of HIV and decrease in CD(4) ( + ) T cell counts
Piguet et al., J Exp Med 1989 (Pulmonary Fibrosis) : Depletion of the CD4 and CD8 T lymphocytes by an in vivo treatment with mAb prevented the bleomycin induced increase of TNF mRNA level and fibrosis
Hershkoviz et al., J Immunol 1994 : When TNF-alpha was immobilized on FN, less TNF-alpha was required to induce CD4+ cell binding to FN. Soluble, and to a greater extent FN-bound, TNF-alpha synergizes with PMA to intensify protein tyrosine phosphorylation in FN-bound CD4+ cells, and this effect of TNF-alpha was inhibited by inhibitors of tyrosine kinase
Oyaizu et al., Blood 1994 : In addition, CD4XL resulted in the induction of interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) in the absence of interleukin-2 (IL-2) and IL-4 secretion in PBMCs
Oyaizu et al., Adv Exp Med Biol 1995 (HIV Infections) : CD4XL in PBMC also resulted in induction of the cytokines INF-tau and TNF-alpha in the absence of IL-2 and IL-4 secretion
Hossain et al., Immunology 1996 : Our data indicate that TNF-alpha induced CD4 expression on human eosinophils is dependent on protein synthesis and may be dependent on tyrosine kinase activity
Tamma et al., Blood 1997 : CD4 cross linking ( CD4XL ) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells ... CD4+ T cells expressing dn-ras secreted significantly reduced levels of TNF-alpha in response to CD4XL
Yu et al., Neuroimmunomodulation 1998 : IL-1-alpha and TNF-alpha differentially regulate CD4 and Mac-1 expression in mouse microglia ... The addition of IL-1alpha, but not TNF-alpha , also led to an increase in CD4 expression on plate supported microglia with a similar dose response and time course