◀ Back to TNF

ADCYAP1 — TNF

Text-mined interactions from Literome

Delgado et al., J Neuroimmunol 1999 (Endotoxemia) : VIP/PACAP inhibit the production of IL-12, IL-6, tumor necrosis factor alpha (TNFalpha) , and interferon gamma (IFNgamma) in vivo in endotoxemic mice
Delgado et al., J Neuroimmunol 1999 : We reported previously that VIP and PACAP inhibit IL-6, IL-12, TNF alpha and NO production, and enhance IL-10 production, from lipopolysaccharide (LPS) stimulated macrophages ... The VIP/PACAP inhibition of TNF alpha and NO occurs through both CD14 dependent and -independent mechanisms, whereas the inhibition of IL-6 production appears to be strictly CD14 dependent
Delgado et al., J Biol Chem 1999 : We showed previously that VIP and PACAP inhibit the production of macrophage derived tumor necrosis factor-alpha , interleukin (IL)-6, nitric oxide, and IL-12
Kim et al., J Neurosci 2000 (Spinal Cord Injuries) : TNF-alpha protein levels were reduced 90 % by VIP or PACAP at 10 ( -7 ) m ... We conclude that VIP and PACAP inhibit the production of TNF-alpha from activated microglia by a cAMP dependent pathway
Leceta et al., Ann N Y Acad Sci 2000 (Inflammation) : VIP/PACAP inhibit the production of TNF alpha , IL-6, IL-12, and nitric oxide ( NO ), and stimulate IL-10 in peritoneal macrophages and Raw 264.7 cells ... VIP/PACAP inhibit TNF alpha through reduction in NFkB binding and changes in the composition of CRE binding complexes ; they inhibit IL-12 through reduction in NFkB binding and changes in the composition of the ets-2 complexes
Delgado et al., J Leukoc Biol 2003 : VIP and PACAP inhibit TNF-alpha , IL-1beta, IL-6, and NO production by lipopolysaccharide (LPS) activated microglia
Yang et al., J Pharmacol Exp Ther 2006 : The critical role of NADPH oxidase for GIF and PACAP38 neuroprotection against LPS induced DA neurotoxicity was demonstrated using neuron-glia cultures from mice deficient in NADPH oxidase ( PHOX ( -/- ) ), where PACAP38 and GIF reduced tumor necrosis factor alpha production and were neuroprotective only in PHOX ( +/+ ) cultures and not in PHOX ( -/- ) cultures
Ait-Ali et al., Neuropharmacology 2010 : By acting downstream of NF-kappaB to inhibit I kappaB alpha gene induction by TNF-alpha, PACAP may block I kappaB alpha dependent negative autoregulation of TNF-alpha signaling through NF-kappaB, prolonging TNF-alpha dependent signaling to neuropeptide encoding genes in chromaffin cells
Li et al., J Mol Neurosci 2011 (Renal Insufficiency) : PACAP38 also reduced plasma and kidney levels of tumor necrosis factor-a and restored collagen IV levels
Delgado et al., J Immunol 1999 : Previous reports showed that VIP/PACAP inhibit IL-6 and TNF-alpha production in LPS stimulated macrophages
Delgado et al., J Immunol 1999 (Inflammation) : VIP and PACAP regulate the production of TNF-alpha at a transcriptional level