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RNF19A — SLPI
Text-mined interactions from Literome
Suzuki et al., Bone 2002
:
Distinct MAPK pathways seem to independently modulate osteoblastic cell proliferation and differentiation, with Erk playing an essential role in cell replication, whereas
p38 is
involved in the regulation of
ALP expression during osteoblastic cell differentiation
Kakita et al., Prostaglandins Leukot Essent Fatty Acids 2004
:
Recently, we have shown that
p38 mitogen activated protein ( MAP ) kinase pathway
regulates ALP activity in response to activation of Gi protein coupled receptors in mouse osteoblast-like MC3T3-E1 cells ( Suzuki et al., Endocrinology 140 ( 1999 ) 3177 )
Rey et al., Bone 2007
(MAP Kinase Signaling System) :
Interestingly, PTH induced
ALP stimulation was dose-dependently
inhibited by a specific
p38 inhibitor with no change in the generation of cAMP and the production of osteocalcin
Qin et al., Int Endod J 2012
:
BMP-2 dose- and time-dependently upregulated phosphorylation of
p38a of HDPCs. Compared with BMP-2-treatment group, gene knock-down of p38a MAPK significantly
inhibited ALP activity and the formation of mineralized nodules in HDPCs