Gene interactions and pathways from curated databases and text-mining

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INS — RNF19A

Text-mined interactions from Literome

Igarashi et al., Eur J Clin Invest 2000 (MAP Kinase Signaling System) : Insulin activated p38 MAP kinase phosphorylation in a dose dependent manner, and the phosphorylation was specifically inhibited by SB-203580, a p38 MAP kinase-specific inhibitor, but not by PD-98059, a specific inhibitor of upstream kinase ( MEK ), of extracellular signal regulated kinase ( ERK ), or GF209203X, a protein kinase C-specific inhibitor
Somwar et al., Diabetes 2000 : Activation of p38 mitogen activated protein kinase alpha and beta by insulin and contraction in rat skeletal muscle : potential role in the stimulation of glucose transport
Kumar et al., Br J Pharmacol 2002 (Insulin Resistance) : Treatment with metformin enhanced the basal activation levels of p38 in both sensitive and resistant myotubes, but insulin did not further stimulate p38 activation in metformin treated cells
Koistinen et al., Diabetologia 2003 (Diabetes Mellitus, Type 2) : Insulin increases p38 MAPK phosphorylation in skeletal muscle from non-diabetic subjects, but not in Type 2 diabetic patients
Hirabara et al., J Nutr Biochem 2013 : These results suggest that long-term fish oil supplementation improves insulin sensitivity in association with increased insulin stimulated p38 activation and decreased n-6 : n-3 ratio in skeletal muscle and decreased global DNA methylation in liver
Yamaguchi et al., Biochim Biophys Acta 2013 (Diabetes Mellitus, Type 1...) : Moreover, p38 inhibitor suppressed Ins ( C96Y ) -induced MIN6 cell death
Kummer et al., J Biol Chem 1997 : Both insulin and PD169316 markedly blocked the increase in p38 activity and apoptosis
Larsen et al., J Biol Chem 1998 : Inhibition of p38 but not of ERK1/2 attenuated IL-1beta mediated inhibition of glucose stimulated insulin release