Hoot et al., J Clin Invest 2010
(Carcinoma, Squamous Cell...) :
Smad2 loss caused increased binding of Smad4 and CBP/p300 to the Hgf promoter
Janknecht et al., Genes Dev 1998
:
We report that TGF-beta receptor phosphorylation of Smad3 promotes its interaction with the paralogous coactivators CBP and p300, whereas CBP/p300 binding to nonphosphorylated Smad3 or its oligomerization partner Smad4 is negatively regulated by Smad-intramolecular interactions ... Thus, CBP/p300 are important components of activin/TGF-beta signaling and may mediate the antioncogenic functions of Smad2 and Smad4