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NAMPT — NFKB1
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Moschen et al., J Immunol 2007
(Inflammation...) :
Visfatin induced effects involve p38 as well as MEK1 pathways as determined by inhibition with MAPK inhibitors and we observed activation of
NF-kappaB
Adya et al., Diabetes Care 2008
(Diabetes Mellitus, Type 2...) :
We investigated the
activation of
nuclear factor-kappaB (NF-kappaB) , a well-known proinflammatory transcription factor, by
visfatin in endothelial cells ...
Visfatin significantly
increased NF-kappaB transcriptional activity ( P < 0.001 ) ...
Visfatin induced
NF-kappaB signaling in human endothelial cells affects the activation of gelatinases MMP-2 and -9, suggesting an important role of visfatin in the pathogenesis of vascular inflammation in obesity and type 2 diabetes
Lee et al., Int J Obes Relat Metab Disord 2009
:
Electrophoretic mobility shift assay confirmed that
visfatin increased the DNA binding activity of
NF-kappaB ... Our findings suggest that
visfatin causes endothelial dysfunction by increasing inflammatory and adhesion molecule expression at least partly through the upregulation of
NF-kappaB activity
Romacho et al., Diabetologia 2009
(Diabetes Mellitus...) :
By using the respective ERK 1/2 and NF-kappaB inhibitors, PD98059 and pyrrolidine dithiocarbamate, we established that iNOS induction by
ePBEF/NAMPT/visfatin required the consecutive upstream activation of ERK 1/2 and
NF-kappaB ... However, exogenous nicotinamide mononucleotide, the product of NAMPT activity, mimicked NF-kappaB activation and iNOS induction by ePBEF/NAMPT/visfatin, while the NAMPT inhibitor APO866 prevented the
effects of
ePBEF/NAMPT/visfatin on iNOS and
NF-kappaB
Kang et al., Diabetes Res Clin Pract 2010
(Diabetes Mellitus, Type 2...) :
These findings suggest that
visfatin synthesis is activated from adipose tissue in a diabetic environment,
induces NF-kappaB activation and leads to activation of pro-inflammatory cytokines and systemic inflammation
Huang et al., Zhonghua Xin Xue Guan Bing Za Zhi 2010
:
NF-kappaB was also
activated in these cells by
visfatin and these effects could be significantly attenuated by Bay11-7082