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HMOX1 — NFKB1
Pathways - manually collected, often from reviews:
-
WikiPathways Oxidative Stress:
NFKB1/SP1/NFE2L2
→
HMOX1/GPX1/GPX3/NQO1/UGT1A6
(activation)
Text-mined interactions from Literome
Lavrovsky et al., Mech Ageing Dev 2000
:
Age dependent increase of
heme oxygenase-1 gene expression in the liver
mediated by
NFkappaB
Vicente et al., Br J Pharmacol 2001
:
Our results suggest that inhibition of
NF-kappaB binding could
mediate the effects of ZM 230,487 on the modulation of
HO-1 and iNOS protein expression
Hassoun et al., Surgery 2002
(Aortic Aneurysm, Abdominal...) :
We examined the effects of regional intraischemic hypothermia on mesenteric I/R induced mucosal injury,
NF-kappaB activation , and expression of iNOS and
HO-1 ... Mesenteric I/R significantly increased intestinal permeability to ( 14 ) C inulin, histologic injury,
activation of
NF-kappaB , and iNOS and
HO-1 expression when compared with sham control rats
Soares et al., J Immunol 2004
(MAP Kinase Signaling System) :
In addition,
HO-1 inhibited the activation of
NF-kappaB , a transcription factor required for TNF-alpha mediated up-regulation of these genes in EC
Chen et al., J Cell Biochem 2004
(Carcinoma, Papillary...) :
Furthermore, we demonstrated that increased levels of HO-1 and p21 expression are associated with an increase in the activity of NF-kappaB and that inhibiting
NF-kappaB leads to a block in the induction of
HO-1 and p21
Wijayanti et al., Antioxid Redox Signal 2004
(MAP Kinase Signaling System) :
Role of
NF-kappaB and p38 MAP kinase signaling pathways in the lipopolysaccharide dependent activation of
heme oxygenase-1 gene expression
Dijkstra et al., J Pathol 2004
(Colonic Neoplasms...) :
Oxidative stress prevented iNOS induction in an
NF-kappaB dependent manner but increased
HO-1 expression in CM-exposed DLD-1 cells
Wu et al., J Card Fail 2004
(Anoxia) :
Furthermore, transfection assay using HO-1 promoter constructs revealed the
involvement of the
nuclear factor kB (NF-kB) and Activator protein-1 (AP-1) in the hypoxia induced activation of the
HO-1 gene
Huang et al., Ann N Y Acad Sci 2005
:
The level of
HO-1 expression and its promoter activity mediated by resveratrol was
attenuated by
nuclear factor-kappa B (NF-kappaB) inhibitors, but not by mitogen activated protein kinase ( MAPK ) inhibitors
Laxmanan et al., J Am Soc Nephrol 2005
:
By electrophoretic mobility shift assay, it was confirmed that CD40 signaling
induced the transcriptional activation of
HO-1 through the binding of
NF-kappaB to its promoter
Pae et al., Atherosclerosis 2006
(Atherosclerosis) :
Based on our findings, we suggest that Nrf2 dependent
HO-1 expression induced by HA
inhibits MCP-1 secretion, VCAM-1 expression and
NF-kappaB activation associated with vascular injury and inflammation in atherosclerosis
Belcher et al., J Clin Invest 2006
(Anemia, Sickle Cell...) :
Treatment of sickle mice with hemin further increases
heme oxygenase-1 expression and
inhibits hypoxia/reoxygenation induced stasis, leukocyte-endothelium interactions, and
NF-kappaB , VCAM-1, and ICAM-1 expression
Tsai et al., Anesthesiology 2006
:
The
effects of
HO-1 induction on nuclear factor E2-related factor 2 ( Nrf2 ) and
nuclear factor kappaB (NF-kappaB) were also investigated
Kim et al., Lung Cancer 2008
(Lung Neoplasms) :
Transfection studies with siRNA specific for Nrf2 and NF-kappaB revealed that
HO-1 expression in A549 cells is
mediated by transcriptional activation of Nrf2, but not
NF-kappaB
Seldon et al., J Immunol 2007
(Inflammation) :
HO-1 inhibits
NF-kappaB ( i.e., RelA ) phosphorylation at Ser ( 276 ), a phosphoacceptor that is critical to sustain TNF-driven NF-kappaB activity in EC
Tranter et al., Free Radic Biol Med 2008
(Inflammation) :
Furthermore,
HO-1 and CO suppress
NF-kappaB activation by IL-18
Hsieh et al., Toxicological sciences : an official journal of the Society of Toxicology 2008
:
Statin induced
heme oxygenase-1 increases
NF-kappaB activation and oxygen radical production in cultured neuronal cells exposed to lipopolysaccharide ... Inhibition of the induced
HO-1 by zinc protoporphyrin
reduced the increased
NF-kappaB activation and superoxides production ... This study revealed that simvastatin induced
HO-1 led to increased
NF-kappaB activation and superoxides production in the neuronal cells when exposed to LPS, and iron production may play a role in such a response
Zhao et al., Immunol Invest 2008
(Inflammation) :
The cellular secretion of TNF-alpha, IL-1beta, IL-6, NO and IL-10 in supernatant, mRNA expression of TNF-alpha, COX-2, iNOS and
HO-1 , protein expression of COX-2 and HO-1, and
activation of
NF-kappaB were assayed by ELISA, the Griess method, real-time quantitative PCR, and Western blot and immunocytochemistry method, respectively
Tsoyi et al., Cell Signal 2008
:
LPS induced
NF-kappaB and STAT-1 activation was partially
prevented by
HO-1 overexpression
Min et al., Int Immunopharmacol 2009
:
Taken together, these results suggest that down-regulation of LPS induced NO production by 5-hydroxyzerumbone is mediated by the suppression of iNOS expression through the modulation of
NF-kappaB activation and
HO-1 induction in macrophage cells
Boost et al., Int J Mol Med 2009
:
We, therefore, aimed to investigate the effects of the volatile anesthetics sevoflurane and isoflurane on
NF-kappaB/IkappaBalpha dependent intracellular signal transduction in human monocytic THP-1 cells induced by tumor necrosis factor-alpha (TNF-alpha) and production of interleukin-8 (IL-8) and downstream
heme oxygenase-1 (HO-1)
Rushworth et al., Cancer Res 2010
(Acute Disease...) :
We show that inhibition of
NF-kappaB increased
HO-1 expression in primary AML cells compared with that of nonmalignant cells
Zhao et al., Zhongguo Ying Yong Sheng Li Xue Za Zhi 2006
(Shock, Septic) :
The
role of activated
nuclear factor-kappa B(NF-kappaB) on the expression of
heme oxygenase-1 induced by lipopolysaccharide (LPS) in rats ' myocardium was obversed, and the effect exerted in endotoxic shock was explored