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HES1 — NEUROD1
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Takatsuka et al., Brain Res 2004
:
Previously, we demonstrated that the bHLH gene
Hes1 inhibits
neuronal differentiation whereas, in Hes1-null retina, precursors prematurely differentiate into neurons and form abnormal rosette-like structures
Bai et al., Dev Cell 2007
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Overexpression of Id2 in the chick hindbrain upregulates
Hes1 expression and
inhibits proneural gene expression and
neuronal differentiation
Zhang et al., Brain Res 2010
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Our results demonstrated that Mash1, Id2, Hes1 were all widely expressed in in vitro progenies from mouse SVZa NPCs. Analyses of SVZa NPCs transfected with eukaryotic expression plasmids showed that Mash1 promoted neuronal differentiation from SVZa NPCs, while Id2 and
Hes1 repressed
neuronal differentiation
Wang et al., Front Biosci (Elite Ed) 2010
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Thus, our results indicate that miR-124 regulates the expression of
Hes-1 at the post-transcriptional level and is
involved in the retinoic acid induced
neuronal differentiation of P19 cells
Tan et al., Genes Cells 2012
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Over-expression of miR-9 negatively regulates the
Hes1 protein expression by interacting with the 3'-UTR of Hes1 mRNA, thereby
inducing cell cycle exit and
neuronal differentiation
Katakura et al., Stem cells international 2013
:
In the present study, we examined the effect of eicosapentaenoic acid ( EPA ) and arachidonic acid ( AA ) on differentiation, expression of basic helix-loop-helix transcription factors ( Hes1, Hes6, and NeuroD ), and the cell cycle of cultured NSCs. EPA also increased mRNA levels of
Hes1 , an
inhibitor of
neuronal differentiation , Hes6, an inhibitor of Hes1, NeuroD, and Map2 mRNA and Tuj-1 positive cells ( a neuronal marker ), indicating that EPA induced neuronal differentiation
Kageyama et al., Int J Biochem Cell Biol 1997
:
Thus,
HES1 regulates brain and eye morphogenesis by inhibiting premature
neuronal differentiation , and the down-regulation of HES1 expression at the right time is required for normal development of the nervous system ... Thus,
HES1 regulates brain and eye morphogenesis by inhibiting premature
neuronal differentiation , and the down-regulation of HES1 expression at the right time is required for normal development of the nervous system
Ohtsuka et al., Cell Tissue Res 1998
:
The expression of
HES-1 , a negative
regulator of the
neuronal differentiation , was upregulated temporarily in accordance with the suppression of the v-myc expression and was downregulated upon the differentiation of HC2S2 cells into neurons