◀ Back to MMP9
MMP27 — MMP9
Text-mined interactions from Literome
Murphy et al., APMIS 1999
:
Gelatinase A, collagenase 3 and
gelatinase B may be
activated by
MT-MMP based mechanisms, as evidenced by both biochemical and cell based studies
Legrand et al., J Cell Biol 1999
:
In vivo and in vitro,
MMP-9 accumulated in migrating HBEC located at the leading edge of a wound and
MMP-9 expression
paralleled cell migration speed
Corbel et al., Eur J Pharmacol 2001
(Acute Disease...) :
Batimastat did not reduce
MMP secretion in BAL fluid but
inhibited MMP-9 activity
Viitanen et al., Res Vet Sci 2001
(Foot Diseases...) :
In contrast, the absolute HA concentration and HA/ COMP,
MMP-2/COMP and MMP-9/COMP ratios were higher in synovial fluid from the DIP-joint of horses with navicular disease, and MMP-2 and
MMP-9 relative activity levels and MMP-2/COMP and MMP-9/ COMP ratios were
increased in fluid from navicular bursae in horses with navicular disease when compared to a control group
Mori et al., Blood 2002
(Leukemia-Lymphoma, Adult T-Cell...) :
The biologic significance of these observations was validated by the following 2 findings
: MMP-9 expression was
increased in primary ATL cells, and plasma
MMP-9 levels were elevated in ATL patients
Yeo et al., Arch Virol 2002
(Respiratory Syncytial Virus Infections) :
Thus, this study concludes that although RSV infection induces
MMP-9 , which can enhance the syncytia formation leading to RSV multiplication and spread it can be
inhibited by
MMP inhibitors
Eagleton et al., J Surg Res 2002
:
Zymography demonstrated a dose dependent
increase in 92-kDa
MMP ( pro-MMP-9 ) activity ( P < 0.001 ) with corresponding increases in
pro-MMP-9 protein ( P = 0.03 ) and mRNA levels ( P = 0.004 )
Yoshioka et al., J Periodontol 2003
:
In this study, we evaluated the cytotoxicity of hydroxamic acid based
MMP inhibitors ( ONO-4817, ONO-MI1-514, and ONO-MI1-570 ), and their inhibitory
effects on
MMP-2 and -9 activities and growth of Porphyromonas gingivalis
Lalu et al., Mol Cell Biochem 2003
(Cardiomyopathies...) :
The
MMP inhibitors significantly improved cardiac function of LPS treated rats ( Ro 31-9790 : 38 +/- 3, doxycycline : 51 +/- 3 mmHg*mL*min ( -1 ) ), had no effect on the loss of MMP-2 activity, and significantly
reduced the
MMP-9 activity in the perfusate
Johnson et al., Circ Res 2004
(Ischemia) :
Our study indicates that angiogenesis triggered by tissue ischemia requires
MMP-9 , which may be
involved in capillary branching, a potential novel role for this
MMP that could be exploited to control angiogenesis
Lorenzl et al., Neuromolecular Med 2004
(Disease Models, Animal...) :
MMP-9 expression as measured via zymography in the substantia nigra was
reduced by the
MMP inhibitor
Kuivanen et al., J Cutan Pathol 2004
(Adenocarcinoma...) :
MMP-7,
MMP-13 , and MMP-19 were
detected abundantly in MMPD, while
MMP-9 was absent
Akahane et al., Exp Cell Res 2004
:
Both recombinant human TIMP-1 and the synthetic
MMP inhibitors, GM6001 and
MMP-2-MMP-9 Inhibitor III, suppressed migration of human dermal microvascular endothelial cells ( HDMVEC ) in a dose dependent fashion
Mali et al., Invest Ophthalmol Vis Sci 2005
(Retinal Degeneration) :
Furthermore, a synthetic
MMP inhibitor
inhibited KCl mediated
MMP-9 upregulation, which led to a significant attenuation of KCl induced retinal damage
Moche et al., Pneumologie 2005
(Lung Neoplasms...) :
MMP and TIMP plasma concentrations were not different in CA vs. CHF, but
MMP-9 , TIMP-1, and TIMP-2 were
increased vs. CON ( p < 0.005, each )
Bindhu et al., Head Neck 2006
(Carcinoma, Squamous Cell...) :
MMP activation , particularly MMP2 and
MMP9 , observed in different cancers, has been shown to be mediated via the transcription factor nuclear factor kappa B (NF-kappaB)
Kimata et al., Allergol Int 2006
:
Glucocorticoids and flavonoids inhibited
MMP-9 production, and TIMPs and
MMP inhibitors
inhibited the gelatinolytic activity of mast cell derived MMP-9
Zozulya et al., J Immunol 2007
:
We show that DCs produce matrix metalloproteinases
(MMP) -2 and -9 and GM6001, an
MMP inhibitor , decreases both baseline and MIP-1alpha induced DC transmigration
Nguyen et al., J Neurochem 2007
(Brain Injuries...) :
In accordance with protection by GM6001, conditioned media collected from MMP-9 null PMNs was less neurotoxic than that collected from wild-type PMNs. Additionally,
MMP inhibition reduced PMN derived ROS ; removal of ROS
reduced PMN derived
MMP-9 activity ; and TNF-alpha inhibition reduced both PMN derived MMP-9 activity and ROS in PMN cultures
Zhou et al., Hum Reprod 2007
:
CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ), as well as the messenger RNA, protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and
MMP-U0126 , a mitogen activated protein/extracellular signal regulated kinase ( MEK ) inhibitor,
inhibited the enhanced invasiveness and activity of
MMP-9 and MMP-in these cells induced by CsA
Lee et al., Stroke 2007
(Cerebral Hemorrhage...) :
We hypothesized that increased
MMP-9 was associated with ICH induced by vascular endothelial growth factor hyperstimulation and that this effect could be
attenuated by nonspecific
MMP inhibition ...
Effects of minocycline, a nonspecific
MMP inhibitor, and pyrrolidine dithiocarbamate, an upstream regulator of MMPs, on
MMP-9 activity and thereby the degree of ICH were also tested
Bonnema et al., J Card Fail 2007
:
As subject age increased,
MMP-2 increased ( from 1188 +/- 99 ng/mL to 1507 +/- 76 ng/mL ), MMP-7
increased ( from 1.2 +/- 0.1 ng/mL to 3.1 +/- 0.6 ng/mL ),
MMP-9 decreased ( from 29 +/- 7 ng/mL to 8 +/- 2 ng/mL ), and TIMP-1, 2, and 4 increased ( from 728 +/- 46 ng/mL to 1093 +/- 73 ng/mL, from 34 +/- 5 ng/mL to 53 +/- 6 ng/mL, and from 1.26 +/- 0.22 ng/mL to 2.34 +/- 0.30 ng/mL, respectively ) ( all P < .05 )
Inamoto et al., Cancer Invest 2007
(Carcinoma, Renal Cell...) :
It was noteworthy that the ras/raf/MEK/ERK pathway inhibitor PD98059 attenuated GABA induced
MMP-9 expression and that both PD98059 and
MMP inhibitors
attenuated the GABA induced invasive activity of Caki-2 cells
Cheng et al., Mol Cell Biochem 2009
:
Here, we show that LPS challenge increased the protein levels of uPA,
MMP-2 and MMP-9, and
induced the activity of MMP-2 and
MMP-9 in H9c2 cardiomyoblasts
Murakami et al., Histol Histopathol 2009
(Dog Diseases...) :
Although
MMP-9 immunoreactivity was n't detected in neoplastic and active angiogenic endothelial cells ( ECs ),
MMP-2 was
detected in all ECs of GTs and in neoplastic cells of both vascular tumors
Yu et al., Cytotechnology 2009
:
Matrine significantly reduced the invasion,
MMP-9/MMP-2 activation , Akt phosphorylation, nuclear factor kappaB p-65 expression and DNA binding activity, and mRNA levels of
MMP-9 , MMP-2, EGF and VEGFR1 in MDA-MB-231 cells
La et al., J Periodontol 2009
:
Grape seed extract suppresses lipopolysaccharide induced
matrix metalloproteinase ( MMP ) secretion by macrophages and
inhibits human
MMP-1 and -9 activities
Teles et al., Infect Immun 2010
(Inflammation...) :
The participation of MMPs in disease was suggested by ( i ) increased MMP mRNA expression levels in skin biopsy specimens correlating with the expression of gamma interferon ( IFN-gamma ) and tumor necrosis factor alpha (TNF-alpha), ( ii ) the detection of the MMP protein and enzymatic activity within the inflammatory infiltrate, ( iii ) increased
MMP levels in patient sera, and ( iv ) the in vitro
induction of
MMP-9 by Mycobacterium leprae and/or TNF-alpha
Shin et al., Neurochem Res 2010
:
In this condition, uPA increased the activity of matrix metalloproteinase (
MMP-9 ) and the inhibition of
MMP activity with pharmacological inhibitors against either uPA ( amiloride ) or MMP ( phenanthrolene and SB-3CT ) effectively
prevented BV2 cell migration
Benson et al., Am J Respir Cell Mol Biol 2011
:
Intracellular calcium flux was augmented in
response to
MMP inhibition or deficiency in the same cells, and IL-2 production was reduced in CD4 ( + ) and CD8 ( + )
MMP9 ( -/- ) T cells
Chen et al., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2010
:
The results showed : ( 1 ) The expression of MMP-9 was weak in static state, however,
MMP-9 expression increased when MSCs were exposed to 15 dyne/cm2 shear stress for 2 hours, and
MMP-9 expression
increased with the extension of stimulating time, and it reached the peak at 24 h ; ( 2 ) MSCs were stimulated by shear stress for 2 hours at different strengths ( 5 dyne/cm2, 15 dyne/cm2, 30 dyne/cm2 ), and under all these conditions, the expression of MMP-9 increased, and reached the peak at 15 dyne/cm2 ; ( 3 ) After MSCs were pretreated by three kinds of signal pathway inhibitors, the expression of MMP-9 did not change obviously in Wortmannin group and PD98059 group, but it was significantly inhibited in SB202190 group
Feng et al., PloS one 2011
(Leukemia) :
However, these alterations reduced when
MMP-2 and -9 activities were
inhibited by RNA interference strategy or by
MMP inhibitor GM6001 in an in vitro BBB model
Kular et al., Journal of neuroinflammation 2012
(Disease Models, Animal...) :
In vitro, results based on cultured DRG neurons showed that siRNA mediated inhibition of NOV
enhanced IL-1ß- and TNF-a induced MMP-2,
MMP-9 and CCL2 expression whereas NOV addition inhibited TNF-a induced
MMP-9 expression through ß1 integrin engagement
Marquis et al., BMC complementary and alternative medicine 2012
(Periodontal Diseases) :
We also investigated the capacity of these compounds to reduce cytokine and
matrix metalloproteinase ( MMP ) secretion by lipopolysaccharide (LPS) stimulated macrophages and to
inhibit MMP-9 activity
Fu et al., Ren Fail 2012
(Fibrosis) :
The expressions of HIF-1a, TGF-ß1,
MMP-9 , and TIMP-1 were elevated and MMp-9/TIMP-1 ratio was lowered in the model group ( p < 0.05 ), but losartan
increased the expression of
MMP-9 and MMp-9/TIMP-1 ratio ( p < 0.05 ) and lessened the expressions of HIF-1a, TGF-ß1, and TIMP-1 ( p < 0.05 )
Quan et al., Clin Exp Metastasis 2013
(Bone Neoplasms...) :
Of factors associated with invasion,
MMP-2 was unchanged and
MMP-9 increased in SCC25 and Tca8113, while MMP-2 was increased and MMP-9 unchanged in HN5
Swamydas et al., Cell Adh Migr 2013
(Mammary Neoplasms, Animal...) :
Additionally, the addition of specific
MMP9/MMP13 and MMP14 inhibitors
prevented the
MMP activities of supernatants collected from 4T1 cells incubated with D1CM, CCL5 or CCL9
Imada et al., Biol Reprod 1997
:
Thus,
MMP-9 and progesterone are very likely to play essential roles in cervical ripening and dilatation in the rabbit, and the production of
MMP-9 in the cervix is finely
regulated during pregnancy