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HMOX1 — MAPK6
Text-mined interactions from Literome
Brouard et al., J Exp Med 2000
:
Expression of
HO-1 or exposure of ECs to exogenous CO
enhanced p38
MAPK activation by TNF-alpha
Ryter et al., Antioxid Redox Signal 2002
(MAP Kinase Signaling System) :
Surprisingly, SB203580, an inhibitor of p38
MAPK , and PD98059, an inhibitor of mitogen activated protein kinase kinase ( MEK1 ), strongly
enhanced hypoxia induced
HO-1 mRNA expression in PAEC
Chen et al., J Cell Biochem 2004
(Carcinoma, Papillary...) :
The induced levels of
HO-1 and p21 were significantly
reduced by p38
mitogen activated protein kinase ( p38 MAPK ) and extracellular regulated kinase (ERK) inhibitors
Anwar et al., Free Radic Biol Med 2005
(Arteriosclerosis...) :
Inhibitors of protein kinase C ( PKC ) or mitogen activated protein kinases (
MAPK ) p38 ( MAPK ) and MEK or c-jun-NH2-terminal kinase ( JNK ) significantly
attenuated induction of
HO-1
Huang et al., Ann N Y Acad Sci 2005
:
The level of
HO-1 expression and its promoter activity mediated by resveratrol was
attenuated by nuclear factor-kappa B (NF-kappaB) inhibitors, but not by
mitogen activated protein kinase ( MAPK ) inhibitors
Ogborne et al., Arterioscler Thromb Vasc Biol 2005
(Leukemia) :
Alpha-lipoic acid induced
heme oxygenase-1 expression is
mediated by nuclear factor erythroid 2-related factor 2 and p38
mitogen activated protein kinase in human monocytic cells
Zwerina et al., FASEB J 2005
(Arthritis, Rheumatoid...) :
Up-regulation of
HO-1 was
mediated by activation of
MAPK and primarily prevented differentiation of osteoclast precursors to osteoclasts, whereas it did not affect mature osteoclasts
McNally et al., Int J Mol Med 2007
:
PKC and p38
MAPK activity are
required for full induction of
HO-1
Cooper et al., Toxicol Appl Pharmacol 2007
:
These findings suggest that the
ERK/MAPK activation is
necessary but not sufficient for optimal arsenite stimulated
HO-1 induction
Kocanova et al., Apoptosis 2007
(MAP Kinase Signaling System...) :
p38 ( MAPK ) inhibitors or small interfering RNA ( siRNA ) for p38 (
MAPK )
suppress HO-1 induction after PDT and complete repression is attained when p38 and PI3K antagonists are combined
Kim et al., Lung Cancer 2008
(Lung Neoplasms) :
In addition, pharmacologic inhibitors of
MAPK suppressed the induction of
HO-1 and Nrf2 expression by cisplatin
Hsu et al., Am J Physiol Regul Integr Comp Physiol 2008
(Hemorrhage...) :
Mechanism of estrogen mediated intestinal protection following trauma-hemorrhage : p38
MAPK dependent upregulation of
HO-1 ... p38
MAPK activation also
results in the induction of
heme oxygenase (HO)-1 , which exerts potent anti-inflammatory effects ... This was accompanied with a decrease in intestinal p38
MAPK activity and
increase in
HO-1 expression
Yang et al., Free Radic Biol Med 2008
(Lymphoma) :
Gallium nitrate increased the phosphorylation of p38
mitogen activated protein kinase and activated Nrf-2, a
regulator of
HO-1 gene transcription
Park et al., Oncol Rep 2008
(Lung Neoplasms) :
MAPK inhibitors
blocked the induction of
HO-1 by combination treatment
Naidu et al., J Immunol 2008
:
The antioxidant N-acetylcysteine and inhibitors of p38
MAPK or serine/threonine kinase CK2
blocked PMA dependent
HO-1 gene activation
Guan et al., J Cell Biochem 2008
(MAP Kinase Signaling System) :
We examined the
role of Mitogen Activated Protein Kinase (
MAPK ) pathways in
HO-1 regulation by EA. Primary rat aortic smooth muscle cells were exposed to EA or physiologic pH
Han et al., J Pharmacol Exp Ther 2009
:
Either phosphatidylinositol 3-kinase or
mitogen activated protein kinase cascade inhibitors
blocked the
HO-1 induction
Rémy et al., J Immunol 2009
:
HO-1 and CO inhibited LPS induced activation of the IFN regulatory factor 3 pathway and their effects were
independent of p38, ERK, and JNK
MAPK
Huang et al., Toxicol Appl Pharmacol 2009
:
Inhibition of the p38
mitogen activated protein kinase pathway significantly
blocked HO-1 induction by METH and aggravated METH neurotoxicity
Park et al., Biochimie 2010
(Colonic Neoplasms) :
The pharmacological inhibition of ERK and p38
MAPK inhibited rottlerin induced
HO-1 up-regulation
Genc et al., Cell Biochem Funct 2010
:
These results suggest that Epo
induces neural
HO-1 expression through the activation of PI3K,
MAPK , and Nrf2 pathways, and this may unveil a novel mechanism which mediates the cytoprotective responses elicited by Epo
Ohnishi et al., Brain Res 2010
(Brain Injuries...) :
Overall, these results suggest that p38
MAPK dependent induction of
HO-1 supports survival of striatal microglia during thrombin insults
Chen et al., Food Chem Toxicol 2010
:
Western blot showed that hesperidin facilitated
ERK/MAPK phosphorylation which appeared to be responsible for nuclear translocation of Nrf2, thereby
inducing cytoprotective
heme oxygenase-1 (HO-1) expression
Seidel et al., Respir Res 2010
(Airway Remodeling) :
HO-1 expression was reversed by GSH-OEt, or p38
MAPK inhibition , or
HO-1 siRNA, which all reversed the anti-proliferative effect of DMF
Carchman et al., Hepatology 2011
(Liver Diseases) :
Sepsis or LPS induced autophagy protects against hepatocellular death, in part via an
HO-1 p38
MAPK dependent signaling
Lee et al., J Cell Biochem 2011
(MAP Kinase Signaling System) :
Small interfering RNA and pharmacological inhibitors of PKC-d and p38
MAPK attenuated
HO-1 induction in fisetin stimulated HUVECs
Liang et al., Mol Cell Biochem 2011
:
The pharmacological inhibition of cJun-N-terminal kinases ( JNKs ) blocked the DMSO induced HO-1 up-regulation, while inhibition of extracellular regulated kinase and
p38-MAPK did not
block heme oxygenase-1 up-regulation
Seidel et al., Eur Respir J 2013
:
DMF inhibited CXCL10 secretion and increased
HO-1 levels, and p38
mitogen activated protein kinase ( MAPK ) inhibition
reduced DMF dependent HO-1 expression
Bang et al., J Ethnopharmacol 2012
(MAP Kinase Signaling System) :
These results suggest that AJ suppresses LPS induced NO production and iNOS expression in macrophages through the inhibition of I?B/NF-?B and
MAPK as well as the Nrf2 mediated
HO-1 induction
Kästle et al., Free Radic Biol Med 2012
(MAP Kinase Signaling System) :
Histone deacetylase 6 (HDAC6) plays a crucial role in
p38MAPK dependent induction of
heme oxygenase-1 (HO-1) in response to proteasome inhibition ... In this study we demonstrate that the up-regulation of
HO-1 on proteasome inhibition is
mediated by
p38MAPK and Nrf-2
Tsai et al., Cellular oncology (Dordrecht) 2012
(Carcinoma, Non-Small-Cell Lung...) :
In addition, we found that
HO-1 expression can be
inhibited by PI3K and AKT inhibitors, but not by
MAPK inhibitors
Liu et al., PloS one 2012
(Shock, Hemorrhagic...) :
These results suggest that the protective effect of tropisetron administration on alleviation of hepatic injury after trauma-hemorrhage is likely mediated through p38
MAPK dependent
HO-1 expression
Wang et al., Apoptosis 2013
:
Furthermore, momordin Ic combination with NAC influenced MAPK, PI3K/Akt and HO-1, iNOS pathways,
MAPK and PI3K/Akt pathways also
regulated the expression of
HO-1 and iNOS
Deng et al., Cell Biol Toxicol 2013
:
Evaluation of signaling pathways showed that a phosphatidylinositol 3-kinase (PI3K) inhibitor ( LY294002 ), but not an ERK 1/2 inhibitor ( PD98059 ) or a p38
MAPK ( SB203580 ), significantly
down-regulated PM2.5 induced Nrf2 nuclear translocation and
HO-1 mRNA expression, indicating PI3K/AKT is involved in the signaling pathway leads to the PM2.5 induced nuclear translocation of Nrf2 and subsequent Nrf2 mediated HO-1 transcription
Gu et al., International journal of medical sciences 2013
(MAP Kinase Signaling System...) :
Additionally, the potential
roles of ERK, p 38
MAPK and JNK in the regulation of propofol induced endogenous
HO-1 expression in SH-SY5Y cells were estimated by Western blotting assays
Elbirt et al., J Biol Chem 1998
(Carcinoma, Hepatocellular...) :
This construct was used to investigate the
role of
mitogen activated protein ( MAP ) kinases in arsenite mediated
heme oxygenase-1 gene expression