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GJA1 — IGF1
Text-mined interactions from Literome
Lin et al., Invest Ophthalmol Vis Sci 2003
:
IGF-I induced phosphorylation of
connexin 43 by PKCgamma : regulation of gap junctions in rabbit lens epithelial cells ... To determine the role of PKCgamma in insulin-like growth factor
(IGF)-I induced phosphorylation of
connexin (Cx)43 and control of gap junctions in lens epithelial cells
Aberg et al., J Neurosci Res 2003
:
Insulin-like growth factor-I increases astrocyte intercellular gap junctional communication and
connexin43 expression in vitro
Lin et al., Invest Ophthalmol Vis Sci 2003
:
Phorbol ester ( TPA ) and insulin-like growth factor
(IGF)-1 recruited PKCgamma into Cav-1 containing lipid rafts and
stimulated the interactions of PKCgamma with Cav-1 and
Cx43 ... Activation of PKCgamma by TPA or
IGF-1 stimulated the interaction of PKCgamma with Cav-1 and
Cx43 in lipid rafts, causing Cx43, Cav-1, and PKCgamma to redistribute within the lipid rafts, and this resulted in a decrease in gap junction plaques
Nguyen et al., J Biol Chem 2004
:
We have shown previously that
insulin-like growth factor-I or lens epithelium derived growth factor
increases the translocation of protein kinase Cgamma ( PKCgamma ) to the membrane and the phosphorylation of
Cx43 by PKCgamma and causes a subsequent decrease of gap junction activity ( Nguyen, T. A., Boyle, D. L., Wagner, L. M., Shinohara, T., and Takemoto, D. J. ( 2003 ) Exp. Eye Res. 76, 565-572 ; Lin, D., Boyle, D. L., and Takemoto, D. J. ( 2003 ) Investig
Jia et al., J Surg Res 2007
:
Angiotensin II and
IGF-1 regulate
connexin43 expression via ERK and p38 signaling pathways in vascular smooth muscle cells of coronary artery bypass conduits ... Using immunohistochemistry, Western blot, and reverse-transcription polymerase chain reaction, we assessed the
effect of Ang II and
IGF-1 stimulation on
connexin43 expression and the signaling pathways involved in VSMCs of SV and IMA ...
IGF-1 dose-dependently
induced mRNA expression of
connexin43 in the VSMCs of SV, which was blocked by PD98059 ... However, in VSMCs of IMA there was no significant
effect of
IGF-1 on the
connexin43 mRNA expression
Jia et al., J Cell Mol Med 2011
:
Cross-talk between angiotensin II and
IGF-1 induced
connexin 43 expression in human saphenous vein smooth muscle cells ... Moreover, AT-II and
IGF-1 induced
Cx43 expression via phosphorylation of Erk 1/2 and activation of transcription factor activator protein 1 (AP-1) through their reciprocal receptors in SV SMCs ... These data demonstrate a cross-talk between IGF-1R and AT-1R in AT-II and
IGF-1 induced
Cx43 expression in SV SMCs involving Erk 1/2 and downstream activation of the AP-1 transcription factor