Gene interactions and pathways from curated databases and text-mining

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HNRNPF — IL2RA

Text-mined interactions from Literome

Mehlhop et al., J Immunol Methods 2002 (Simian Acquired Immunodeficiency Syndrome) : In general, macaque DCs exhibited weaker responses to LPS and Poly I:C than human DCs, and soluble CD40L stimulation induced variable expression of CD25
Gorczynski et al., Transplantation 2005 : In the presence of anti-CD200R2/3 monoclonal antibodies ( mAbs ), bone-marrow cells cultured in the presence of ( interleukin [IL]-4+granulocyte-macrophage colony stimulating factor ) differentiate into dendritic cells (DCs) , which induce CD4CD25Treg
Ahn et al., Int Immunol 2007 : We sought to characterize the effects of dendritic cells (DCs) on the in vitro regulatory activity of CD4 ( + ) CD25 ( + ) T cells obtained from peripheral blood of healthy human donors
Luo et al., Proc Natl Acad Sci U S A 2007 (Diabetes Mellitus, Type 1) : Here we show that beta-cell peptide pulsed dendritic cells (DCs) from nonobese diabetic ( NOD ) mice can effectively induce CD4 ( + ) CD25 ( + ) Foxp3 ( + ) T cells from naïve islet-specific CD4 ( + ) CD25 ( - ) T cells in the presence of TGF-beta1 ... These results indicate a role for DCs in the induction of antigen-specific CD4 ( + ) CD25 ( + ) Foxp3 ( + ) T cells that can inhibit fully developed autoimmunity in a nonlymphopoenic host, providing an important potential strategy for immunotherapy in patients with autoimmune diabetes
Torisu et al., J Gastroenterol 2008 (Autoimmune Diseases...) : Taken together, these results suggest that increased induction of CD4 ( + ) CD25 ( + ) regulatory T cells by Reg-DCs might contribute to downregulation of inflammatory processes and autoantibody production during AIG development in mice
Silva-Campa et al., Virology 2009 (Porcine Reproductive and Respiratory Syndrome) : Our results showed that PRRSV infected DCs significantly increased Foxp3 ( + ) CD25 ( + ) T cells, an effect that was reversible by IFN-alpha treatment, and this outcome was reproducible using two distinct PRRSV strains
Mnasria et al., Transplant Proc 2009 (Acute Disease) : In this study, we observed that stimulation of human monocyte derived DCs with lipopolysa ccharide or CD40L strongly induced the expression of CD25
Brenk et al., J Immunol 2009 : Moreover, ILT3 ( high ) ILT4 ( high ) DCs lead to the induction of CD4 ( + ) CD25 ( + ) Foxp3 ( + ) T regulatory cells with suppressive activity from CD4 ( + ) CD25 ( - ) T cells
Zhu et al., J Interferon Cytokine Res 2009 : DCs treated with HMGB1 ( 1 microg/mL for 48 h ) promoted T-cell proliferation as well as differentiation, and markedly up-regulated IL-2, IL-2R expression and intranuclear NF-kappaB activation
Zhou et al., Clin Dev Immunol 2010 : These results suggested that lactadherin could adjust intestinal DCs activity, induce CD3 ( + ) CD4 ( + ) CD25 ( + ) T cell differentiation, and enhance IL-10 production
Pothoven et al., Am J Transplant 2010 : This work addresses whether rapamycin conditioned donor DCs could effectively induce CD4 ( + ) CD25 ( + ) Foxp3 ( + ) Tregs ( iTregs ) in cell cultures with alloantigen specificities, and whether such in vitro differentiated CD4 ( + ) CD25 ( + ) Foxp3 ( + ) iTregs could effectively control acute rejection in allogeneic islet transplantation
Nishimura et al., Xenotransplantation 2010 : Porcine cell pulsed DCs stimulated CD4 ( + ) T cells, and CD4 ( + ) CD25 ( + ) regulatory T cells suppressed this response
Zhao et al., Eur J Cancer 2012 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : CML-MSC-DCs derived TGF-ß1 was largely responsible for the increase in CD4+CD25+Foxp3+Tregs based on knockdown studies
Cecere et al., Vet Microbiol 2012 (Coinfection...) : DCs infected with PCV2 significantly increased CD4 ( + ) CD25 ( + ) FoxP3 ( + ) T ( regs ) ( p < 0.05 ) and DCs co-infected with PRRSV and PCV2 induced significantly higher numbers of T ( regs ) than with PCV2 alone ( p < 0.05 )
Ramos et al., J Leukoc Biol 2012 (Breast Neoplasms) : In cancer, DCs may play a dysfunctional role in the induction of CD4 ( + ) CD25 ( + ) Foxp3 ( + ) Tregs, contributing to immune evasion