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DBT — EPO
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Gao et al., Planta Med 2008
:
In addition, the
DBT induced
EPO expression could be abolished by pre-treatment with U0126, a mitogen activated kinase inhibitor
Zheng et al., J Ethnopharmacol 2010
:
Pharmacological results indicate that
DBT can
stimulate the production of
erythropoietin (EPO) , a specific hematopoietic growth factor, in cultured cells ... In order to reveal the mechanism of DBT 's hematopoietic function, this study investigated the activity of the
DBT induced
EPO expression and the upstream regulatory cascade of EPO via hypoxia induced signaling in cultured kidney fibroblasts ( HEK293T ) ... Our study indicates that HIF pathway plays an essential role in directing
DBT induced
EPO expression in kidney