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EFNA2 — EPHA5

Pathways - manually collected, often from reviews:

• KEGG Axon guidance: EFNA1/EFNA2/EFNA3/EFNA4/EFNA5 → EPHA1/EPHA2/EPHA3/EPHA4/EPHA5/EPHA6/EPHA7/EPHA8 (protein-protein, activation)
  
• NCI Pathway Database EPHA forward signaling: None → Ephrin A2/EPHA3-4-5-6-7 complex (EFNA2-EPHA7_EPHA6_EPHA5_EPHA3_EPHA4) (modification, collaborate)
  Gallo et al., J Cell Biol 2002
  Evidence: mutant phenotype
• NCI Pathway Database EPHA forward signaling: Ephrin A2/EPHA3-4-5-6-7 complex (EFNA2-EPHA7_EPHA6_EPHA5_EPHA3_EPHA4) → RHOA/GTP complex (RHOA) (modification, activates) Gallo et al., J Cell Biol 2002
  Evidence: mutant phenotype
• NCI Pathway Database EPHA forward signaling: Ephrin A2/EPHA3-4-5-6-7 complex (EFNA2-EPHA7_EPHA6_EPHA5_EPHA3_EPHA4) → RHOA/GDP complex (RHOA) (modification, activates) Gallo et al., J Cell Biol 2002
  Evidence: mutant phenotype
• NCI Pathway Database EPHA forward signaling: Ephrin A2/EPHA3-4-5-6-7 complex (EFNA2-EPHA7_EPHA6_EPHA5_EPHA3_EPHA4) → None (modification, activates) Gallo et al., J Cell Biol 2002
  Evidence: mutant phenotype
• NCI Pathway Database EPHA forward signaling: Ephrin A2 (EFNA2) → Ephrin A2/EPHA3-4-5-6-7 complex (EFNA2-EPHA7_EPHA6_EPHA5_EPHA3_EPHA4) (modification, collaborate)
  Gale et al., Neuron 1996
  Evidence: physical interaction
• NCI Pathway Database EPHA forward signaling: Ephrin A2 (EFNA2) → EPHA3-4-5-6-7 (EPHA7/EPHA6/EPHA5/EPHA3/EPHA4) (modification, collaborate)
  Gale et al., Neuron 1996
  Evidence: physical interaction
• NCI Pathway Database EPHA forward signaling: Ephrin A2/EPHA3-4-5-6-7 complex (EFNA2-EPHA7_EPHA6_EPHA5_EPHA3_EPHA4) → EPHA3-4-5-6-7 (EPHA7/EPHA6/EPHA5/EPHA3/EPHA4) (modification, collaborate)
  Gale et al., Neuron 1996
  Evidence: physical interaction
• Reactome Reaction: EFNA2 → EPHA5 (direct_complex) Himanen et al., Nature 2001, Himanen et al., Trends Neurosci 2003, Himanen et al., Curr Opin Cell Biol 2007, Himanen et al., EMBO Rep 2009
• Reactome Reaction: EFNA2 → EPHA5 (indirect_complex)
• Reactome Reaction: EFNA2 → EPHA5 (reaction) Marignani et al., J Cell Biol 2001, Himanen et al., Nature 2001, Himanen et al., Trends Neurosci 2003, Marston et al., Nat Cell Biol 2003, Cowan et al., Neuron 2005, Himanen et al., Curr Opin Cell Biol 2007, Himanen et al., EMBO Rep 2009

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: EPHA5 — EFNA2 (in vivo) Gerlai et al., J Neurosci 1999*

Text-mined interactions from Literome

Holmberg et al., Genes Dev 2005 : We here report the identification of an additional mechanism to control cell number in the brain : EphA7 induces ephrin-A2 reverse signaling, which negatively regulates neural progenitor cell proliferation
Nie et al., Nat Neurosci 2010 : We also found that EphA receptor activation by ephrin-A ligands in neurons led to inhibition of extracellular signal regulated kinase 1/2 ( ERK1/2 ) activity and decreased inhibition of Tsc2 by ERK1/2
Petty et al., PloS one 2012 (Neoplasm Metastasis...) : During tumor progression, EphA2 receptor can gain ligand independent pro-oncogenic functions due to Akt activation and reduced ephrin-A ligand engagement