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CD4 — RUNX3

Text-mined interactions from Literome

Ehlers et al., J Immunol 2003 : Using this approach, we show here that the transcription factor Runx3 is involved in silencing of CD4 expression during CD8 T cell differentiation
Kohu et al., J Immunol 2005 : Runx3 overexpression also increased the number of mature CD4 ( - ) 8 ( + ) thymocytes in mice with class II-restricted, transgenic TCR and in mice with a class I-deficient background, both of which are favorable for CD4 ( + ) 8 ( - ) lineage selection
Grueter et al., J Immunol 2005 (Lymphopenia...) : Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells ... In addition, transgenic overexpression of Runx3 reduced CD4 expression during development of DP thymocytes, leading to a reduced number of CD4 SP thymocytes and an increased number of CD8 SP thymocytes
Yarmus et al., Proc Natl Acad Sci U S A 2006 : These data provide evidence for the requirement of Groucho/TLE for Runx3 mediated epigenetic silencing of CD4 and pertain to the mechanism through which other Runx3 regulated genes are epigenetically silenced
Wildt et al., J Immunol 2007 : We demonstrate that, although Zbtb7b does not enhance CD4 expression on its own, it antagonizes the CD4 repression mediated by the transcription factor Runx3 , which is normally up-regulated during CD8 differentiation and promotes CD4 silencing
Xiong et al., Eur J Immunol 2013 : The transcription factor Runx3 inhibits CD4 ( + ) T-cell differentiation by repressing Cd4 gene expression ; accordingly, Runx3 is not expressed in DP thymocytes or developing CD4 ( + ) T cells ... Furthermore, whereas Runx3 represses Cd4 , we show that Gata3 promotes Cd4 expression in Thpok-deficient thymocytes
Reis et al., Nat Immunol 2013 (Colitis...) : Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4 ( + ) T cell immunity