Gene interactions and pathways from curated databases and text-mining

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CD4 — ITGAX

Text-mined interactions from Literome

García-Martínez et al., J Immunol 2004 : CD11c ( + ) dendritic cells develop and function normally in mice with a mutated CD83 gene but CD4 ( + ) T cell development is substantially reduced
Su et al., Infect Immun 2005 (Malaria...) : Splenic CD11c ( + ) dendritic cells ( DC ) from mice infected with malaria alone and coinfected mice showed similarly increased expression of CD40, CD80, and CD86, but DC from coinfected mice were unable to induce CD4 ( + ) T-cell proliferation and optimal IFN-gamma production in response to the malaria antigen in vitro
Anis et al., Infect Immun 2008 (Mycobacterium Infections) : CD11c ( + ) lung cells from BCG infected mice activated ovalbumin ( OVA ) -specific naïve CD4 ( + ) T cells more than CD11c ( + ) lung cells from uninfected mice
Fujiwara et al., Am J Physiol Gastrointest Liver Physiol 2011 (Colitis...) : In transfer models of CD4 ( + ) T cell induced colitis, small numbers ( 2.5 x 10 ( 5 ) ) of SI CD11c ( + ) CD8 ( + ) T cells suppressed proinflammatory cytokine producing CD4 ( + ) T cells in mesenteric lymph nodes and mucosa associated lymphoid compartments ( SI and LI ) and protected mice from chronic inflammation