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CD4 — IRF4

Text-mined interactions from Literome

Tominaga et al., Int Immunol 2003 (Leishmaniasis, Cutaneous) : To further investigate the role of IRF-4 in CD4 ( + ) T cell function, IRF-4 ( -/- ) mice were challenged with the intracellular pathogen Leishmania major
Tamura et al., J Immunol 2005 : We found that IRF-4 is required for the generation of CD4 ( + ) DCs, whereas IRF-8 is, as reported previously, essential for CD8alpha ( + ) DCs
Cao et al., Eur J Immunol 2010 : Similar to the effect of Runx3 deficiency, transgenic expression of IRF4 led not only to an aberrantly high expression of CD4 surface molecules on intermediate CD4 ( + ) CD8 ( low ) cells and CD8 SP thymocytes, but also impaired CD8 ( + ) T-cell function ... Taken together, our data suggest that IRF4 plays an important role in the regulation of Runx3 expression and CD4 ( + ) /CD8 ( + ) thymocyte differentiation
Bruhn et al., Allergy 2012 (Rhinitis, Allergic, Seasonal) : IRF4 increased in allergen challenged CD4 ( + ) cells from patients with IAR, and functional studies supported its role in Th2 cell activation
Biswas et al., J Exp Med 2012 (Autoimmune Diseases...) : In CD4 ( + ) T helper cells, IRF4 plays an essential role in the regulation of IL-21 production, whereas in B cells it controls class switch recombination and plasma cell differentiation